Gerber M A
Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
J Hepatol. 1995;22(1 Suppl):83-6.
Hepatitis C virus (HCV) is the main cause of non-A, non-B hepatitis around the world. It frequently leads to chronic hepatitis which may progress to cirrhosis and hepatocellular carcinoma (HCC). Characteristic, although not pathognomonic, histologic changes in chronic hepatitis C include bile duct damage and lymphoid aggregates in portal tracts. Hepatocyte and bile duct injury seem to be mediated by both a direct cytopathic effect of HCV and immune mechanisms, perhaps triggered by HCV. Most HCC are related to HCV, HBV, or both. HCV appears to persist and replicate in hepatocytes during malignant transformation, but it is not clear whether the virus plays a direct or indirect role in hepatocarcinogenesis.
丙型肝炎病毒（HCV）是全球非甲非乙型肝炎的主要病因。它常导致慢性肝炎，后者可能进展为肝硬化和肝细胞癌（HCC）。慢性丙型肝炎的特征性组织学改变（虽非特异性）包括胆管损伤和汇管区淋巴样聚集。肝细胞和胆管损伤似乎是由HCV的直接细胞病变效应以及免疫机制介导的，可能由HCV触发。大多数肝细胞癌与HCV、HBV或两者均有关。在恶性转化过程中，HCV似乎在肝细胞中持续存在并复制，但尚不清楚该病毒在肝癌发生中是起直接还是间接作用。
