Barros Costa D L, Chantegrel J, Alves de Lima M C, Cavalcanti Albuquerque J M, Correa Lima R M, Galdino S L, Pitta I R, Luu-Duc C
Departamento de Antibioticos, Universidade Federal de Pernambuco, Brésil.
J Pharm Belg. 1995 Jan-Feb;50(1):5-10.
Synthesis and physico-chemical properties of nine 3-(4-fluoro or chlorobenzyl)-5-arylidène-imidazolidine-2,4-diones, four 3-(4-fluoro or bromobenzyl)-5-arylidène-thiazolidine-2,4-diones and three 3-)4-bromophénacyl)-5-arylidène-thiazolidine-2,4- diones has been described. These compounds were synthesized by aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted imidazolidine-2,4-diones or thiazolidine-2,4-diones. In vitro cytotoxic activity was determined for compounds 8, 17, 18, 21 and 22.
已描述了九种3-(4-氟或氯苄基)-5-亚芳基-咪唑烷-2,4-二酮、四种3-(4-氟或溴苄基)-5-亚芳基-噻唑烷-2,4-二酮和三种3-(4-溴苯甲酰基)-5-亚芳基-噻唑烷-2,4-二酮的合成及其物理化学性质。这些化合物是通过芳香醛与3-取代的咪唑烷-2,4-二酮或噻唑烷-2,4-二酮的羟醛缩合-巴豆酰化反应合成的。测定了化合物8、17、18、21和22的体外细胞毒性活性。
