Brandão S S, Rocha Filho J A, Chantegrel J, Albuquerque J F, Ximenes E A, Galdino S L, Pitta I R, Perrissin M, Luu-Duc C
Departamento de Antibióticos, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Brasil.
Ann Pharm Fr. 1997;55(5):206-11.
Synthesis and physico-chemical properties of four 3-benzyl or 3-(4-chlorobenzyl)-4-thioxo-5-arylazo-imidazolidin-2-ones, five 3-(4-nitrobenzyl)-5-arylidenethiazolidine-2,4-diones and three 3-(4-phenyl-phenacyl)-4-thioxo-5-arylidenethiazolidin-2-ones have been described. These new products were synthesized by an aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted thioxothiazolidin-2-ones or thiazolidine-2,4-diones. The arylazo-imidazolidine compounds were synthesized by copulation of diazonium ions with imidazolidines. Antimicrobial activity was determined for some compounds.
已描述了四种3-苄基或3-(4-氯苄基)-4-硫代-5-芳基偶氮咪唑啉-2-酮、五种3-(4-硝基苄基)-5-芳亚基噻唑烷-2,4-二酮和三种3-(4-苯基苯甲酰基)-4-硫代-5-芳亚基噻唑烷-2-酮的合成及其物理化学性质。这些新产品是通过芳香醛与3-取代的硫代噻唑烷-2-酮或噻唑烷-2,4-二酮的羟醛缩合-巴豆酰化反应合成的。芳基偶氮咪唑啉化合物是通过重氮离子与咪唑啉的偶合反应合成的。测定了某些化合物的抗菌活性。
