杨梅树皮对实验性肝损伤的保护作用

[Protective effects of the bark of Myrica rubra Sieb. et Zucc. on experimental liver injuries].

作者信息

Ohta S, Sakurai N, Kamogawa A, Yaguchi Y, Inoue T, Shinoda M

机构信息

Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

出版信息

Yakugaku Zasshi. 1992 Apr;112(4):244-52. doi: 10.1248/yakushi1947.112.4_244.

DOI:10.1248/yakushi1947.112.4_244

PMID:1403657

Abstract

The methanol extract from the bark of Myrica rubra SIEB. et ZUCC. showed protective effects on liver injuries induced by carbon tetrachloride (CCl4) and alpha-naphthylisothiocyanate (ANIT) in rats. In this study, the fractions and some compounds from the bark of M. rubra were investigated for the protection against CCl4 inducing liver injuries in rats. The active principles for the protection were recognized in two fractions (M-3 and M-5 Fr. 1) obtained from the methanol extract, and one of the active principles in the fraction (M-3) was found to be myricanol 5-O-beta-D-(6'-O-galloyl)-glucopyranoside. In addition, these fractions protecting liver injuries induced by CCl4 showed significant protective effects against cholestasis induced by ANIT.

摘要

杨梅（Myrica rubra SIEB. et ZUCC.）树皮的甲醇提取物对四氯化碳（CCl4）和α-萘异硫氰酸酯（ANIT）诱导的大鼠肝损伤具有保护作用。在本研究中，对杨梅树皮的提取物和一些化合物进行了研究，以探讨其对CCl4诱导的大鼠肝损伤的保护作用。从甲醇提取物中获得的两个组分（M-3和M-5 Fr. 1）具有保护活性，其中组分M-3中的一种活性成分被鉴定为杨梅醇5-O-β-D-（6'-O-没食子酰基）-吡喃葡萄糖苷。此外，这些对CCl4诱导的肝损伤具有保护作用的组分对ANIT诱导的胆汁淤积也显示出显著的保护作用。