Bellini M, Spataro M, Costa F, Tumino E, Ciapparrone G, Flandoli F, Rucco M, Maltinti G, Marchi S
Clinica Medica I, Università di Pisa.
Minerva Med. 1995 Mar;86(3):75-80.
Sonographic measurement of gallbladder volume has allowed us to assay the influence of many substances (hormones, drugs, etc.) on gallbladder kinetics playing a pivotal role in digestive mechanisms. The aim of the present study has been to evaluate the effect of an alkaline bicarbonate water (Donata) on gallbladder emptying. The study was performed in cross-over. Ten healthy volunteers randomly assumed alkaline bicarbonate water or saline (400 ml). Gallbladder volumes were measured by ultrasonography, according to ellipsoid method, before and 15', 30', 45', 60', 90', 120' after water or saline intake. A week later the test was repeated. Gallbladder kinetics was evaluated referring to fasting volume, residual volume, absolute emptying and maximum percent emptied. Student's "t" test for paired data was used for statistical evaluation of the results. Gallbladder volumes were significantly reduced 15', 30', 45' and 60' after alkaline bicarbonate water administration, whereas saline did not induced gallbladder emptying. The present results suggest that Donata water may be employed in order to ameliorate dyspepsia due to biliary dyskinesia, moreover it may play a complementary role in the prevention and in the medical treatment of biliary lithiasis.
超声测量胆囊容积使我们能够分析许多物质（激素、药物等）对在消化机制中起关键作用的胆囊动力学的影响。本研究的目的是评估碱性碳酸氢盐溶液（多纳塔）对胆囊排空的作用。该研究采用交叉试验。10名健康志愿者随机饮用碱性碳酸氢盐溶液或生理盐水（400毫升）。根据椭球体法，在摄入水或生理盐水之前以及之后15分钟、30分钟、45分钟、60分钟、90分钟和120分钟，通过超声测量胆囊容积。一周后重复该试验。参照空腹容积、残余容积、绝对排空量和最大排空百分比评估胆囊动力学。采用配对数据的学生“t”检验对结果进行统计学评估。饮用碱性碳酸氢盐溶液后15分钟、30分钟、45分钟和60分钟，胆囊容积显著减小，而生理盐水未引起胆囊排空。目前的结果表明，多纳塔水可用于改善因胆囊运动障碍引起的消化不良，此外，它在胆结石的预防和药物治疗中可能起到辅助作用。
