Mehra M R, Lavie C J, Ventura H O, Milani R V
Ochsner Clinic, Department of Cardiology, New Orleans, LA 70121, USA.
Postgrad Med. 1995 Jul;98(1):175-6, 179-84.
Evidence is increasing that oxidation of low-density lipoprotein cholesterol may be instrumental in atherogenesis. As a result, a number of studies have been undertaken to evaluate the effects of antioxidant vitamins, beta carotene, selenium, and monounsaturated fat on coronary artery disease. Results in many instances have been promising, particularly in the case of vitamin E supplements. Studies of pro-oxidants, such as iron and copper, are inconclusive at this time, and a trial to assess the value of probucol in hypercholesterolemic patients is currently under way.
越来越多的证据表明，低密度脂蛋白胆固醇的氧化可能在动脉粥样硬化的形成中起作用。因此，已经进行了多项研究来评估抗氧化维生素、β-胡萝卜素、硒和单不饱和脂肪对冠状动脉疾病的影响。在许多情况下，结果是有希望的，特别是在补充维生素E的情况下。目前，关于铁和铜等促氧化剂的研究尚无定论，一项评估普罗布考在高胆固醇血症患者中的价值的试验正在进行中。
