Folsom A R, Ma J, Eckfeldt J H, Nieto F J, Metcalf P A, Barnes R W
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015, USA.
Ann Epidemiol. 1995 May;5(3):186-91. doi: 10.1016/1047-2797(94)00105-3.
We examined the association of serum albumin concentration with diabetes mellitus and other cardiovascular risk factors, prevalent cardiovascular disease, and ultrasonographically assessed carotid artery intima-media thickness using data from 45- to 64-year-old adults in the Atherosclerosis Risk in Communities (ARIC) Study. The mean albumin concentration was 0.04 to 0.12 g/L lower in participants with diabetes and 0.02 to 0.06 g/L lower in those with cardiovascular disease, compared to participants without these conditions. However, lower serum albumin level was also correlated with most traditional risk factors and hemostatic variables. On adjustment for these, there was essentially no association between serum albumin and prevalent cardiovascular disease. Likewise, there was no association between albumin and carotid intima-media thickness (a marker of atherosclerosis). While hypoalbuminemia may be a marker for chronic disease and perhaps renal loss of albumin, it seems unlikely that it is an important cause of atherosclerosis.
我们利用社区动脉粥样硬化风险（ARIC）研究中45至64岁成年人的数据，研究了血清白蛋白浓度与糖尿病及其他心血管危险因素、心血管疾病患病率以及超声评估的颈动脉内膜中层厚度之间的关联。与无糖尿病和心血管疾病的参与者相比，糖尿病参与者的平均白蛋白浓度低0.04至0.12g/L，心血管疾病参与者的平均白蛋白浓度低0.02至0.06g/L。然而，较低的血清白蛋白水平也与大多数传统危险因素和止血变量相关。在对这些因素进行调整后，血清白蛋白与心血管疾病患病率之间基本无关联。同样，白蛋白与颈动脉内膜中层厚度（动脉粥样硬化的一个标志物）之间也无关联。虽然低白蛋白血症可能是慢性疾病的一个标志物，也可能提示白蛋白经肾脏丢失，但它似乎不太可能是动脉粥样硬化的一个重要病因。
