Werth E, Borbély A A
Institute of Pharmacology, University of Zurich, Switzerland.
Electroencephalogr Clin Neurophysiol. 1995 Jun;94(6):406-13. doi: 10.1016/0013-4694(94)00337-k.
The aim of the study was to examine whether the typical changes of the EEG in the course of a sleep episode can be recorded by skin electrodes placed at the outer canthi of the eyes. In sleep recording from young, healthy subjects, the signals from the electro-oculogram (EOG, E1-A2) derivation and a central scalp EEG derivation (C3-A2) were compared. Sleep stage scores obtained separately from each of the two signals yielded highly corresponding values with the exception of stages 2 and 4, for which there were discrepancies. Both signals were subjected to spectral analysis to compare the spectra and their evolution during sleep. An automated detection routine served to identify and eliminate epochs contaminated by eye movement potentials. The typical time course of EEG slow-wave activity (SWA; power density in the 0.75-4.5 Hz range) could be derived from both signals with only minor differences between the data sets. However, compared to the EEG spectra, power density of the EOG spectra was attenuated in frequencies higher than 2 Hz and the typical changes in the spindle frequency range were not evident. The results show that the major sleep parameters as well as the dynamics of SWA can be reliably determined from signals recorded from periorbital skin electrodes.
本研究的目的是检验放置于眼外眦的皮肤电极能否记录睡眠过程中脑电图（EEG）的典型变化。在对年轻健康受试者进行睡眠记录时，比较了来自眼电图（EOG，E1 - A2）导联和头皮中央EEG导联（C3 - A2）的信号。从这两个信号分别获得的睡眠阶段评分除了在第2和第4阶段存在差异外，其余值高度对应。对两个信号均进行频谱分析，以比较睡眠期间的频谱及其演变。采用自动检测程序来识别和消除受眼动电位污染的时段。EEG慢波活动（SWA；0.75 - 4.5 Hz范围内的功率密度）的典型时间进程可从两个信号中得出，数据集之间仅有微小差异。然而，与EEG频谱相比，EOG频谱的功率密度在高于2 Hz的频率处衰减，且纺锤波频率范围内的典型变化不明显。结果表明，主要睡眠参数以及SWA的动态变化可从眶周皮肤电极记录的信号中可靠地确定。
