Innis R B, Seibyl J P, Scanley B E, Laruelle M, Abi-Dargham A, Wallace E, Baldwin R M, Zea-Ponce Y, Zoghbi S, Wang S
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06510.
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11965-9. doi: 10.1073/pnas.90.24.11965.
[123I][(1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane] ([123I]beta-CIT) labels dopamine transporters and is, therefore, a marker of neurons that degenerate in Parkinson disease. Single photon emission computed tomography imaging with [123I]beta-CIT showed that radioactivity in striatal regions in healthy subjects increased during a 2-day imaging study, whereas that in Parkinsonian patients peaked earlier at reduced levels relative to healthy subjects. Kinetic analyses of radioactivity in plasma and brain suggest that this decrease was due to an approximately 65% loss of target sites in patients compared with healthy subjects; greater losses occurred in putamen than in caudate. All patients showed lateralized differences in striatal uptake, with greater losses in the striatum contralateral to the side of the body with initial symptoms. These preliminary results suggest that [123I]beta-CIT is a marker for the loss of striatal dopamine terminals in patients with Parkinson disease. Single photon emission computed tomographic imaging with [123I]beta-CIT may be useful for early diagnosis of the disorder, for monitoring the progression of the disease, and for distinguishing the idiopathic disorder from other Parkinsonian syndromes with more widespread pathology.
[123I](1R)-2β-甲氧羰基-3β-(4-碘苯基)托烷可标记多巴胺转运体，因此是帕金森病中发生退变的神经元的标志物。用[123I]β-CIT进行单光子发射计算机断层扫描成像显示，在一项为期2天的成像研究中，健康受试者纹状体区域的放射性增加，而帕金森病患者纹状体区域的放射性在较低水平时比健康受试者更早达到峰值。对血浆和脑内放射性的动力学分析表明，与健康受试者相比，患者靶位点损失约65%，导致了这种放射性降低；壳核的损失比尾状核更大。所有患者纹状体摄取均存在侧化差异，初始症状侧对侧纹状体的损失更大。这些初步结果表明，[123I]β-CIT是帕金森病患者纹状体多巴胺终末损失的标志物。用[123I]β-CIT进行单光子发射计算机断层扫描成像可能有助于该疾病的早期诊断、监测疾病进展以及将特发性疾病与其他具有更广泛病理改变的帕金森综合征区分开来。
