磺胺嘧啶在营养不良中的代谢
Metabolism of sulphadiazine in malnutrition.
作者信息
Arunkumar Shastri R, Krishnaswamy K
出版信息
Br J Clin Pharmacol. 1979 Jan;7(1):69-73. doi: 10.1111/j.1365-2125.1979.tb00899.x.
Abstract
- The kinetics of sulphadiazine were studied in well-nourished and under-nourished subjects. 2. The metabolic clearance rate of a single dose of sulphadiazine given either orally or intravenously was faster in under-nourished subjects. 3. The plasma protein binding of the drug was found to be reduced in under-nourished subjects. 4. Blood concentrations (48 h and 72 h) of sulphadiazine tended to be low in the under-nourished as compared with well-nourished subjects after administration of multiple doses of the drug. 5. It is concluded that a revision in the dosage schedule may not be necessary in the treatment of under-nourished subjects with sulphadiazine, since the blood concentrations were higher than the reporte d minimum to combat infection.
摘要
- 对营养良好和营养不良的受试者的磺胺嘧啶动力学进行了研究。2. 口服或静脉注射单剂量磺胺嘧啶后，营养不良受试者的代谢清除率更快。3. 发现该药物在营养不良受试者中的血浆蛋白结合率降低。4. 多次给药后，与营养良好的受试者相比，营养不良受试者的磺胺嘧啶血药浓度（48小时和72小时）往往较低。5. 得出的结论是，用磺胺嘧啶治疗营养不良的受试者可能无需调整给药方案，因为血药浓度高于报道的抗感染最低浓度。
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