影响老年患者血浆中药物结合的因素。
Factors affecting drug binding in plasma of elderly patients.
作者信息
Wallace S, Whiting B
出版信息
Br J Clin Pharmacol. 1976 Apr;3(2):327-30. doi: 10.1111/j.1365-2125.1976.tb00611.x.
Abstract
The binding of salicylate, sulphadiazine and phenylbutazone to plasma proteins has been studied in young and elderly subjects. Elderly patients had significantly reduced concentrations of plasma albumin, compared with subjects under 40 years of age. Sifnificant increases in free levels of all three drugs were found in elderly patients receiving multiple drug therapy, and a correlation obtained with the number of drugs being taken. It is suggested that because of their low albumin levels, elderly patients may be more susceptible to the effects of multiple drug therapy on drug binding. The clinical implications of these observations are discussed.
摘要
已在年轻和老年受试者中研究了水杨酸盐、磺胺嘧啶和保泰松与血浆蛋白的结合情况。与40岁以下的受试者相比，老年患者的血浆白蛋白浓度显著降低。在接受多种药物治疗的老年患者中，发现所有三种药物的游离水平均显著升高，且与所服用药物的数量存在相关性。有人认为，由于老年患者白蛋白水平较低，他们可能更容易受到多种药物治疗对药物结合的影响。文中讨论了这些观察结果的临床意义。
相似文献
1
Factors affecting drug binding in plasma of elderly patients.影响老年患者血浆中药物结合的因素。
Br J Clin Pharmacol. 1976 Apr;3(2):327-30. doi: 10.1111/j.1365-2125.1976.tb00611.x.
2
Decreased drug binding in serum from patients with chronic hepatic disease.慢性肝病患者血清中药物结合力降低。
Eur J Clin Pharmacol. 1976 Mar 22;09(5-6):429-32. doi: 10.1007/BF00606560.
3
Effect of protein concentration on the binding of drugs to human serum albumin--I. Sulfadiazine, salicylate and phenylbutazone.蛋白质浓度对药物与人血清白蛋白结合的影响——I. 磺胺嘧啶、水杨酸盐和保泰松
Biochem Pharmacol. 1979 Mar 15;28(6):751-6. doi: 10.1016/0006-2952(79)90354-x.
4
Protein binding of drugs in plasma from patients with acute renal failure.
Acta Pharmacol Toxicol (Copenh). 1973;32(6):417-29. doi: 10.1111/j.1600-0773.1973.tb01488.x.
5
Plasma protein carbamylation and decreased acidic drug protein binding in uremia.尿毒症时血浆蛋白氨甲酰化及酸性药物蛋白结合率降低
Clin Pharmacol Ther. 1980 May;27(5):612-8. doi: 10.1038/clpt.1980.87.
6
An analysis of the effect of hypoalbuminemia on the amount of free drug in plasma for drugs bound at two sets of sites.低白蛋白血症对与两组位点结合的药物血浆中游离药物量的影响分析。
Res Commun Chem Pathol Pharmacol. 1974 Dec;9(4):681-8.
7
Factors affecting drug-protein binding in the plasma of newborn infants.影响新生儿血浆中药物与蛋白质结合的因素。
Br J Clin Pharmacol. 1976 Jun;3(3):510-2. doi: 10.1111/j.1365-2125.1976.tb00630.x.
8
Aspects of multiple binding of anticoagulants and other drugs.抗凝剂及其他药物的多重结合方面
Gen Pharmacol. 1977;8(1):7-12. doi: 10.1016/0306-3623(77)90057-x.
9
10
Salicylate protein binding in serum from young and elderly subjects as measured by diafiltration.
Eur J Clin Pharmacol. 1985;28(3):339-45. doi: 10.1007/BF00543334.
引用本文的文献
1
Deep Learning for Drug Development: Using CNNs in MIA-QSAR to Predict Plasma Protein Binding of Drugs.深度学习在药物研发中的应用：利用 CNN 在 MIA-QSAR 中预测药物的血浆蛋白结合率。
AAPS PharmSciTech. 2023 Nov 14;24(8):232. doi: 10.1208/s12249-023-02686-6.
2
Repository Describing the Anatomical, Physiological, and Biological Changes in an Obese Population to Inform Physiologically Based Pharmacokinetic Models.描述肥胖人群解剖学、生理学和生物学变化以支持基于生理学的药代动力学模型的知识库。
Clin Pharmacokinet. 2022 Sep;61(9):1251-1270. doi: 10.1007/s40262-022-01132-3. Epub 2022 Jun 14.
3
Correlation between measured and calculated free phenytoin serum concentration in neurointensive care patients with hypoalbuminemia.低白蛋白血症神经重症监护患者中游离苯妥英血清浓度测量值与计算值之间的相关性
Clin Pharmacol. 2018 Dec 13;10:183-190. doi: 10.2147/CPAA.S186322. eCollection 2018.
4
Repository Describing an Aging Population to Inform Physiologically Based Pharmacokinetic Models Considering Anatomical, Physiological, and Biological Age-Dependent Changes.描述人口老龄化的知识库，用于为考虑到解剖学、生理学和生物学年龄相关变化的基于生理学的药代动力学模型提供信息。
Clin Pharmacokinet. 2019 Apr;58(4):483-501. doi: 10.1007/s40262-018-0709-7.
5
Oral anticancer drugs in the elderly: an overview.老年患者的口服抗癌药物：概述
Drugs Aging. 2007;24(5):395-410. doi: 10.2165/00002512-200724050-00004.
6
Cardiovascular drug therapy in the elderly: theoretical and practical considerations.老年人的心血管药物治疗：理论与实践考量
Drugs Aging. 2003;20(6):445-63. doi: 10.2165/00002512-200320060-00004.
7
Pharmacokinetic and pharmacodynamic changes in the elderly. Clinical implications.老年人的药代动力学和药效学变化。临床意义。
Clin Pharmacokinet. 1998 Jul;35(1):49-64. doi: 10.2165/00003088-199835010-00004.
8
Lornoxicam. A review of its pharmacology and therapeutic potential in the management of painful and inflammatory conditions.氯诺昔康。对其在疼痛和炎症性疾病管理中的药理学及治疗潜力的综述。
Drugs. 1996 Apr;51(4):639-57. doi: 10.2165/00003495-199651040-00008.
9
Characteristics of plasma protein binding of tacrine hydrochloride: a new drug for Alzheimer's disease.盐酸他克林的血浆蛋白结合特性：一种治疗阿尔茨海默病的新药。
Eur J Clin Pharmacol. 1994;47(2):151-5. doi: 10.1007/BF00194965.
10
Pharmacokinetics in the elderly.老年人的药代动力学。
Environ Health Perspect. 1994 Dec;102 Suppl 11(Suppl 11):119-24. doi: 10.1289/ehp.94102s11119.
本文引用的文献
1
Rapid determination of salicylate in biological fluids.生物流体中水杨酸盐的快速测定。
Biochem J. 1954 Jun;57(2):301-3. doi: 10.1042/bj0570301.
2
Studies on the epidemiology of adverse drug reactions. V. Clinical factors influencing susceptibility.药物不良反应的流行病学研究。V. 影响易感性的临床因素。
Ann Intern Med. 1966 Oct;65(4):629-40. doi: 10.7326/0003-4819-65-4-629.
3
Predisposing factors in adverse reactions to drugs.药物不良反应的诱发因素。
Br Med J. 1969 Mar 1;1(5643):536-9. doi: 10.1136/bmj.1.5643.536.
4
Effect of age and sex on human drug metabolism.年龄和性别对人体药物代谢的影响。
Br Med J. 1971 Sep 11;3(5775):607-9. doi: 10.1136/bmj.3.5775.607.
5
Interindividual differences in the protein binding of sulfonamides: the effect of disease and drugs.磺胺类药物蛋白结合的个体间差异：疾病和药物的影响。
Acta Pharmacol Toxicol (Copenh). 1971;29 Suppl 3:134-51. doi: 10.1111/j.1600-0773.1971.tb03293.x.
6
Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.药物代谢随年龄增长的变化：2. 苯妥英钠清除率与蛋白结合率
Br J Clin Pharmacol. 1975 Feb;2(1):73-9. doi: 10.1111/j.1365-2125.1975.tb00475.x.
7
Changes in drug metabolism with increasing age: 1. warfarin binding and plasma proteins.药物代谢随年龄增长的变化：1. 华法林与血浆蛋白的结合
Br J Clin Pharmacol. 1975 Feb;2(1):69-72. doi: 10.1111/j.1365-2125.1975.tb00474.x.
Zotero 插件