Monsell E M, Cody D D, Bone H G, Divine G W, Windham J P, Jacobson G P, Newman C W, Patel S C
Department of Otolaryngology-Head and Neck Surgery, Henry Ford Hospital, Detroit, MI, USA.
Hear Res. 1995 Mar;83(1-2):114-20. doi: 10.1016/0378-5955(94)00196-w.
We have developed a unique method of quantitative computed tomography (QCT) that enables measurement of the density of the cochlear capsule in vivo. We performed pure-tone audiometry and QCT on 67 ears from 35 subjects with radiographically confirmed Paget's disease of the skull and on 40 ears from twenty volunteer subjects. The Pearson product-moment correlation coefficients (age- and sex-adjusted) in the group affected by Paget's disease were -0.63 for left ears and -0.73 for right ears for high-frequency air conduction pure-tone thresholds (mean of 1, 2, and 4 kHz) versus cochlear capsule density. Correlation coefficients (age- and sex-adjusted) between cochlear capsule density and air-bone gap (mean at 0.5 and 1 kHz) for the affected group were -0.67 for left ears and -0.63 for right ears. All correlations between hearing thresholds and cochlear capsule density in pagetic subjects were significant at p < 0.001. The regressions were consistent throughout the ranges of hearing level. There were no significant correlations between cochlear capsule mean density and hearing level in the volunteer subjects. These findings demonstrate the feasibility of precise and accurate density measurements in the temporal bone in vivo and support the use of the mean cochlear capsule density as a marker of disease effect. Alteration of cochlear capsule bone density may be related to the mechanisms of hearing loss in Paget's disease of bone.
我们开发了一种独特的定量计算机断层扫描（QCT）方法，该方法能够在体内测量耳蜗囊密度。我们对35名经影像学证实患有颅骨佩吉特病的受试者的67只耳朵以及20名志愿者受试者的40只耳朵进行了纯音听力测定和QCT检查。在受佩吉特病影响的组中，高频气导纯音阈值（1、2和4 kHz的平均值）与耳蜗囊密度之间的Pearson积矩相关系数（经年龄和性别调整），左耳为-0.63，右耳为-0.73。受影响组中，耳蜗囊密度与气骨导差（0.5和1 kHz处的平均值）之间的相关系数（经年龄和性别调整），左耳为-0.67，右耳为-0.63。佩吉特病受试者的听力阈值与耳蜗囊密度之间的所有相关性在p<0.001时均具有统计学意义。在整个听力水平范围内，回归结果一致。在志愿者受试者中，耳蜗囊平均密度与听力水平之间无显著相关性。这些发现证明了在体内颞骨中进行精确和准确密度测量的可行性，并支持将耳蜗囊平均密度用作疾病影响的标志物。耳蜗囊骨密度的改变可能与骨佩吉特病听力损失的机制有关。
