Monsell E M, Bone H G, Cody D D, Jacobson G P, Newman C W, Patel S C, Divine G W
Department of Otolaryngology--Head and Neck Surgery, Henry Ford Hospital, Detroit, MI 48202, USA.
Am J Otol. 1995 Jan;16(1):27-33.
Auditory brainstem responses (ABRs) were recorded in 64 ears with radiographically confirmed Paget's disease involving the skull. Responses were absent in eight ears, all of which had elevated high pure-tone thresholds. Auditory brainstem responses were interpreted as normal in 56 ears; none were abnormal. Computed tomography and digital image analysis were used to quantify internal auditory canal (IAC) dimensions. The midlength diameter and minimum diameter of the IAC of 68 temporal bones from subjects with Paget's disease were found to have no statistically significant relation to hearing thresholds. Increased IAC length showed a limited relation to reduced hearing level in pagetic subjects, possibly consistent with bossing adjacent to the porus acusticus. Findings support the principle that hearing loss in Paget's disease of bone is generally associated with intact auditory nerve function and also support a cochlear site of lesion.
对64例经影像学证实患有累及颅骨的佩吉特病的患者的64只耳朵进行了听觉脑干反应（ABR）记录。8只耳朵未引出反应，所有这些耳朵的高纯音阈值均升高。56只耳朵的听觉脑干反应被解释为正常；无一异常。使用计算机断层扫描和数字图像分析来量化内耳道（IAC）尺寸。发现患有佩吉特病的受试者的68块颞骨的IAC的中长度直径和最小直径与听力阈值无统计学显著关系。IAC长度增加与佩吉特病患者听力水平降低的关系有限，这可能与靠近耳孔处的骨质增生有关。这些发现支持骨佩吉特病中的听力损失通常与完整的听神经功能相关这一原则，也支持病变位于耳蜗的观点。
