用菜籽油喂养大鼠对肌肉、脂肪组织和肝脏脂肪酶活性的影响。

Alteration of the lipase activities of muscle, adipose tissue and liver by rapeseed oil feeding of rats.

作者信息

Hülsmann W C, Geelhoed-Mieras M M, Jansen H, Houtsmuller U M

出版信息

Biochim Biophys Acta. 1979 Jan 29;572(1):183-7. doi: 10.1016/0005-2760(79)90214-5.

Abstract

Feeding rapeseed oil, rich in erucic acid, for 4 days results in a significant increase of the lipoprotein lipase activities of heart and adipose tissue. The lipase activity of liver, which in earlier studies has been shown to be releasable by heparin perfusion, also increases by the dietary regimen. The increased lipoprotein lipase activity of heart may contribute to lipid accumulation in this organ. The higher intracellular lipid store probably results in higher (hormone-sensitive) tissue lipase activity. The increase of lipoprotein lipase of adipose tissue, however, is not accompanied by an increase of hormone-stimulated tissue lipase activity in fat cells. This activity may even become lower, and might contribute to the decrease of the lipid store in heart after an initial rapid phase of fat accumulation during erucic acid feeding.

摘要

喂食富含芥酸的菜籽油4天会导致心脏和脂肪组织的脂蛋白脂肪酶活性显著增加。肝脏的脂肪酶活性，在早期研究中已表明可通过肝素灌注释放，也会因饮食方案而增加。心脏脂蛋白脂肪酶活性的增加可能导致该器官脂质蓄积。细胞内脂质储存增加可能导致（激素敏感的）组织脂肪酶活性升高。然而，脂肪组织脂蛋白脂肪酶的增加并未伴随脂肪细胞中激素刺激的组织脂肪酶活性增加。这种活性甚至可能降低，并且可能在喂食芥酸期间脂肪蓄积的初始快速阶段后，导致心脏脂质储存减少。