前列腺素产生的组织特异性调节：大鼠肾细胞溶质对6-酮前列腺素F1α生物合成的刺激作用
Tissue specific regulation of prostaglandin production: stimulation of 6-ketoprostaglandin F1alpha biosynthesis by rat kidney cytosol.
作者信息
Morita I, Murota S I
出版信息
Biochim Biophys Acta. 1979 Jan 4;582(1):173-8. doi: 10.1016/0304-4165(79)90300-3.
PMID:760816
Abstract
Boiled cytosol of various rat tissues each affected prostaglandin biosynthesis by bovine seminal vesicle microsomes in a specific way. Kidney cytosol enhanced 6-ketoprostaglandin F1alpha production in a dose-dependent manner. This stimulatory effect was lost after dialysis. Liver, spleen and carrageenin granuloma cytosol inhibited 6-ketoprostaglandin F1alpha production but enhanced prostaglandin E2 production.
摘要
各种大鼠组织的煮沸胞质溶胶均以特定方式影响牛精囊微粒体的前列腺素生物合成。肾胞质溶胶以剂量依赖性方式增强6-酮前列腺素F1α的产生。透析后这种刺激作用消失。肝、脾和角叉菜胶肉芽肿胞质溶胶抑制6-酮前列腺素F1α的产生，但增强前列腺素E2的产生。
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