家族性自身免疫性重症肌无力：四个家族的报告。
Familial autoimmune myasthenia gravis: report of four families.
作者信息
Evoli A, Batocchi A P, Zelano G, Uncini A, Palmisani M T, Tonali P
机构信息
Institute of Neurology, Catholic University, Rome, Italy.
出版信息
J Neurol Neurosurg Psychiatry. 1995 Jun;58(6):729-31. doi: 10.1136/jnnp.58.6.729.
Abstract
Four families each with two patients with autoimmune myasthenia gravis or related conditions are reported. All clinical forms of myasthenia gravis were represented and different disease types were found within the same family. Either one or two generations could be affected and no association with a single HLA haplotype was found. The frequency of familial autoimmune myasthenia gravis is very low and the genetic factors involved seem to be different from MHC genes.
摘要
本文报告了四个家庭，每个家庭中有两名自身免疫性重症肌无力或相关病症患者。重症肌无力的所有临床类型均有体现，且在同一家庭中发现了不同的疾病类型。可能有一代或两代人受到影响，并且未发现与单一HLA单倍型存在关联。家族性自身免疫性重症肌无力的发生率非常低，所涉及的遗传因素似乎与MHC基因不同。
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