Robertson N, Deans J, Fraser M, Compston D A
University of Cambridge Neurology Unit, Addenbrooke's Hospital, UK.
J Neurol Neurosurg Psychiatry. 1995 Jul;59(1):71-6. doi: 10.1136/jnnp.59.1.71.
The Cambridgeshire multiple sclerosis register was established in 1989 and initially reported a prevalence of 130/10(5) population for south and east Cambridgeshire (south Cambs). This survey has now been extended to the northern county districts where there were 449 patients with multiple sclerosis in population of 378,959 on 1 July 1993 (118/10(5); 95% confidence interval (95% CI) 108-130). Four hundred and four had either definite or probable disease (107/10(5); 95% CI: 98-118). This matches the highest figures in the series of seven epidemiological surveys carried out in southern England over the past decade. Comparison with these and other studies indicates that no latitudinal gradient of disease is found in southern England despite spanning four degrees of latitude.
剑桥郡多发性硬化症登记处成立于1989年，最初报告剑桥郡南部和东部（南剑桥郡）的患病率为130/10⁵人口。这项调查现已扩展到北部县区，1993年7月1日，在378,959人的人口中有449例多发性硬化症患者（118/10⁵；95%置信区间（95%CI）108 - 130）。404例患有确诊或可能的疾病（107/10⁵；95%CI：98 - 118）。这与过去十年在英格兰南部进行的七次流行病学调查系列中的最高数字相符。与这些研究及其他研究的比较表明，尽管跨越了四个纬度，但在英格兰南部未发现疾病的纬度梯度。
