Ford H L, Gerry E, Airey C M, Vail A, Johnson M H, Williams D R
Department of Neurology, St Jame's University Hospital, Leeds, UK.
J Neurol Neurosurg Psychiatry. 1998 May;64(5):605-10. doi: 10.1136/jnnp.64.5.605.
To determine the prevalence of multiple sclerosis in the Leeds Health District.
Multiple sources of case ascertainment were used-namely, neurology departments, hospital episode statistics, general practitioners, the Leeds branch of the Multiple Sclerosis Society, the West Yorkshire Multiple Sclerosis Therapy Centre, community physiotherapists and occupational therapists, the Leeds Wheelchair Centre, and the Young Disabled Unit. Data collection was from retrospective analysis of hospital and primary care case records. A population based incidence register was established by prospectively registering all new patients with diagnoses of multiple sclerosis.
On prevalence day, 30 April 1996, 712 people with multiple sclerosis were identified living in Leeds (population 732,061), giving a prevalence of 97/10(5). The prevalence for definite and probable multiple sclerosis was 84/10(5), and for suspected multiple sclerosis it was 13/10(5). The sex ratio of prevalent people with multiple sclerosis was 2.79 to 1 women to men. The mean age of prevalent cases was 51 years, the mean age at symptom onset was 34 years, and the mean duration of disease was 16 years. Forty cases were prospectively reported as incident cases from 1 November 1995 to 1 February 1996.
The prevalence of multiple sclerosis in Leeds was found to be similar to that in the south of the United Kingdom but lower than that in Scotland. There is no evidence of a latitudinal gradient of increasing prevalence of multiple sclerosis from the south to the north of England.
确定利兹健康区多发性硬化症的患病率。
采用多种病例确诊来源，即神经科、医院病历统计、全科医生、多发性硬化症协会利兹分会、西约克郡多发性硬化症治疗中心、社区物理治疗师和职业治疗师、利兹轮椅中心以及青年残疾单元。通过对医院和初级保健病例记录进行回顾性分析来收集数据。通过前瞻性登记所有诊断为多发性硬化症的新患者，建立了基于人群的发病率登记册。
在患病率统计日，即1996年4月30日，确定有712名多发性硬化症患者居住在利兹（人口732,061），患病率为97/10⁵。确诊和疑似多发性硬化症的患病率为84/10⁵，疑似多发性硬化症的患病率为13/10⁵。多发性硬化症患者的性别比为女性与男性2.79比1。患病病例的平均年龄为51岁，症状出现时的平均年龄为34岁，疾病平均持续时间为16年。从1995年11月1日至1996年2月1日，前瞻性报告了40例新发病例。
发现利兹多发性硬化症的患病率与英国南部相似，但低于苏格兰。没有证据表明从英格兰南部到北部多发性硬化症患病率存在纬度梯度增加的情况。
