持续性麻疹病毒和犬瘟热病毒感染对C6大鼠星形细胞瘤细胞中内皮素受体mRNA合成的下调作用。
Downregulation of endothelin receptor mRNA synthesis in C6 rat astrocytoma cells by persistent measles virus and canine distemper virus infections.
作者信息
Meissner N N, Koschel K
机构信息
Institut für Virologie und Immunbiologie, Universität Würzburg, Germany.
出版信息
J Virol. 1995 Aug;69(8):5191-4. doi: 10.1128/JVI.69.8.5191-5194.1995.
Abstract
Persistent infections of C6 rat astrocytoma cells with measles (subacute sclerosing panencephalitis [SSPE]) virus (C6/SSPE cells) or canine distemper virus (C6/CDV cells) cause a loss of endothelin-1 (ET-1) binding to its specific receptors (ETRA type) and subsequent ET-1-induced Ca2+ signaling. It was the aim of this study to investigate the underlying mechanism of this phenomenon in more detail. By using an RNase protection assay, it was found that ETRA mRNA disappears, whereas other cellular mRNA species, e.g., beta-actin mRNA, were not influenced. The data show that the loss of the ET-1 signaling pathway in C6/SSPE and C6/CDV cells is due to a receptor downregulation at the transcriptional level.
摘要
用麻疹（亚急性硬化性全脑炎[SSPE]）病毒（C6/SSPE细胞）或犬瘟热病毒（C6/CDV细胞）持续感染C6大鼠星形细胞瘤细胞，会导致内皮素-1（ET-1）与其特异性受体（ETRA型）的结合丧失，以及随后ET-1诱导的Ca2+信号传导丧失。本研究的目的是更详细地研究这一现象的潜在机制。通过使用核糖核酸酶保护试验，发现ETRA mRNA消失，而其他细胞mRNA种类，如β-肌动蛋白mRNA，未受影响。数据表明，C6/SSPE和C6/CDV细胞中ET-1信号通路的丧失是由于转录水平上的受体下调。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Restriction of fusion protein mRNA as a mechanism of measles virus persistence.限制融合蛋白mRNA作为麻疹病毒持续存在的一种机制。
Virology. 1994 Aug 1;202(2):665-72. doi: 10.1006/viro.1994.1388.
3
Measles virus antisense sequences specifically cure cells persistently infected with measles virus.麻疹病毒反义序列可特异性治愈持续感染麻疹病毒的细胞。
Virology. 1995 Feb 20;207(1):168-78. doi: 10.1006/viro.1995.1063.
4
Brain tubulin and actin cDNA sequences: isolation of recombinant plasmids.脑微管蛋白和肌动蛋白cDNA序列：重组质粒的分离
Nucleic Acids Res. 1980 Aug 25;8(16):3553-64. doi: 10.1093/nar/8.16.3553.
5
Molecular cloning and expression in streptomyces lividans of a hygromycin B phosphotransferase gene from Streptomyces hygroscopicus.吸水链霉菌潮霉素B磷酸转移酶基因在变铅青链霉菌中的分子克隆与表达
Biochem Biophys Res Commun. 1983 Nov 30;117(1):6-12. doi: 10.1016/0006-291x(83)91533-4.
6
Effect of antibody-induced modulation of measles (SSPE) virus membrane proteins on beta-adrenergic receptor-mediated adenylate cyclase activity.
Virology. 1983 Jun;127(2):299-308. doi: 10.1016/0042-6822(83)90145-9.
7
The nucleotide sequence of the rat cytoplasmic beta-actin gene.大鼠细胞质β-肌动蛋白基因的核苷酸序列。
Nucleic Acids Res. 1983 Mar 25;11(6):1759-71. doi: 10.1093/nar/11.6.1759.
8
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.从含有噬菌体SP6启动子的质粒中高效体外合成生物活性RNA和RNA杂交探针。
Nucleic Acids Res. 1984 Sep 25;12(18):7035-56. doi: 10.1093/nar/12.18.7035.
9
Differentiated rat glial cell strain in tissue culture.组织培养中的分化大鼠神经胶质细胞系。
Science. 1968 Jul 26;161(3839):370-1. doi: 10.1126/science.161.3839.370.
10
Replication of measles virus in human lymphocytes.麻疹病毒在人淋巴细胞中的复制。
J Exp Med. 1985 Jun 1;161(6):1261-71. doi: 10.1084/jem.161.6.1261.
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