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麻疹病毒与犬瘟热病毒之间的抗原关系：动物和人类对个别病毒特异性多肽的免疫反应比较。

Antigenic relationships between measles and canine distemper viruses: comparison of immune response in animals and humans to individual virus-specific polypeptides.

作者信息

Stephenson J R, ter Meulen V

出版信息

Proc Natl Acad Sci U S A. 1979 Dec;76(12):6601-5. doi: 10.1073/pnas.76.12.6601.

DOI:10.1073/pnas.76.12.6601
PMID:293747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC411914/
Abstract

Precipitation with hyperimmune rabbit sera, sera from patients convalescing from measles, and sera from patients with subacute sclerosing panencephalitis, followed by electrophoresis, enabled antigenic relationships between the individual polypeptides of measles and canine distemper viruses to be examined. Virus isolates from patients with acute measles or subacute sclerosing panencephalitis showed no antigenic differences. With rabbit hyperimmune sera, antigenic crossreactivity was present between all polypeptides of measles and canine distemper viruses except H. The N polypeptides showed the highest degree of crossreactivity and were interpreted as group-specific antigens. Both convalescent measles sera and sera from subacute sclerosing panencephalitis showed high antibody titers to all measles polypeptides except L and M. However, these sera contained only low activities to the N and F1 polypeptides from canine distemper virus.

摘要

用超免疫兔血清、麻疹恢复期患者血清和亚急性硬化性全脑炎患者血清进行沉淀反应，随后进行电泳，从而能够检测麻疹病毒和犬瘟热病毒各多肽之间的抗原关系。来自急性麻疹患者或亚急性硬化性全脑炎患者的病毒分离株未显示出抗原差异。用兔超免疫血清检测时，麻疹病毒和犬瘟热病毒的所有多肽之间都存在抗原交叉反应，但H多肽除外。N多肽显示出最高程度的交叉反应，被认为是群特异性抗原。麻疹恢复期血清和亚急性硬化性全脑炎患者血清对除L和M之外的所有麻疹多肽均显示出高抗体滴度。然而，这些血清对犬瘟热病毒的N和F1多肽只有低活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/cc691a1e877c/pnas00012-0588-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/2972ef93e234/pnas00012-0586-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/ee7a19fd5682/pnas00012-0586-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/388a49ce9f21/pnas00012-0587-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/414aeba132c3/pnas00012-0587-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/45a09ba4d663/pnas00012-0587-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/b336d5900451/pnas00012-0587-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/cc691a1e877c/pnas00012-0588-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/2972ef93e234/pnas00012-0586-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/ee7a19fd5682/pnas00012-0586-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/388a49ce9f21/pnas00012-0587-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/414aeba132c3/pnas00012-0587-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/45a09ba4d663/pnas00012-0587-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/b336d5900451/pnas00012-0587-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2899/411914/cc691a1e877c/pnas00012-0588-a.jpg

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本文引用的文献

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