Gräsbeck A, Rorsman B, Hagnell O, Håvik M, Hansson F
Department of Psychiatry, Lund University, Sweden.
Neuropsychobiology. 1995;31(3):113-9. doi: 10.1159/000119180.
The aim of the present study was to search for specific premorbid background factors of 'anxiety' in a normal population, the 1947 Lundby cohort. 2,550 probands were repeatedly examined by psychiatrists during a 25-year period, regardless of medical care. The semi-structured examinations included items referring to the proband's mental and physical health, personality, behaviour and socio-economic background. In the present study, only assessments made before the first onset of anxiety were considered. Very strict criteria of 'healthiness' and anxiety regarding the comparison groups were used. Five out of 50 items considered were significantly predictive. The male features share certain similarities with those observed in earlier predictor studies on anxiety and depressive disorders, while the traits found in women seem to predispose for other mental illness as well.
本研究的目的是在1947年隆德比队列这一正常人群中寻找“焦虑症”特定的病前背景因素。在25年的时间里，2550名先证者接受了精神科医生的反复检查，无论其是否接受医疗护理。半结构化检查包括涉及先证者的精神和身体健康、个性、行为及社会经济背景的项目。在本研究中，仅考虑焦虑首次发作之前所做的评估。在比较组方面，采用了关于“健康”和焦虑的非常严格的标准。在50个被考虑的项目中，有5个具有显著的预测性。男性特征与早期关于焦虑症和抑郁症的预测性研究中观察到的特征有一定相似之处，而在女性中发现的特征似乎也易引发其他精神疾病。
