Department of Clinical Sciences, Division of Psychiatry, Lund University Hospital, S-221 85 Lund, Sweden.
Department of Clinical Sciences, Division of Psychiatry, Lund University Hospital, S-221 85 Lund, Sweden.
J Affect Disord. 2018 Mar 1;228:125-131. doi: 10.1016/j.jad.2017.11.038. Epub 2017 Nov 24.
Depression is a common disorder in both men and women, and the recurrence rate is high. The aim of this study was to identify risk factors for recurrence in depression in the Lundby Study.
The Lundby Study is a community-based longitudinal study with focus on mental health. The study started in 1947 and three follow-ups have been carried out since, the last one in 1997. The population consists of 3563 subjects. Data from 508 subjects afflicted by depression was gathered. Premorbid factors (gender, socioeconomic status, marital status, personality and heredity) and factors related to the first depressive episode (age, degree of impairment and melancholic depression) were investigated regarding their influence on the risk for recurrence in depression. Multiple logistic regression was used in the calculations.
Risk factors associated with recurrent depression were melancholic depression at first onset (OR 3.52 [95% CI 1.62-7.66, p < 0.001]), young age as compared to old age at first onset (OR 0.51 [95% CI 0.28-0.92, p = 0.03]) and a premorbid nervous/tense personality (OR 1.77 [95% CI 1.22-2.56, p < 0.01]). Demographic factors, including gender, had no effect on the odds of recurrence.
The Lundby Study spans over 50 years, making the results vulnerable to changes in diagnostic regimes and recall bias.
Melancholia at onset, regardless of severity of symptoms, had the greatest impact on the risk of recurrence in depression in the Lundby Study. Information about risk factors for recurrence in depression are useful in offering effective preventive measures in the form of psychotropic drugs and psychotherapy, and deciding the length of follow-up.
抑郁症在男性和女性中都很常见，且复发率较高。本研究旨在确定 Lundby 研究中抑郁症复发的风险因素。
Lundby 研究是一项以社区为基础的纵向研究，重点关注心理健康。该研究始于 1947 年，此后进行了三次随访，最近一次是在 1997 年。该人群由 3563 名受试者组成。收集了 508 名患有抑郁症的受试者的数据。研究了发病前的因素（性别、社会经济地位、婚姻状况、个性和遗传）以及与首次抑郁发作相关的因素（年龄、受损程度和忧郁性抑郁症），以调查其对抑郁症复发风险的影响。计算中使用了多变量逻辑回归。
与复发性抑郁症相关的风险因素包括首次发作时的忧郁性抑郁症（OR 3.52[95%CI 1.62-7.66，p < 0.001]）、首次发作时年龄较年轻（OR 0.51[95%CI 0.28-0.92，p = 0.03]）和发病前紧张/紧张的个性（OR 1.77[95%CI 1.22-2.56，p < 0.01]）。人口统计学因素，包括性别，对复发的几率没有影响。
Lundby 研究跨越了 50 多年，因此结果容易受到诊断方案变化和回忆偏倚的影响。
在 Lundby 研究中，无论症状严重程度如何，忧郁症的发作对抑郁症复发的风险影响最大。关于抑郁症复发风险因素的信息对于提供有效的预防措施，如精神药物和心理治疗，以及决定随访时间长短都很有用。
