Hagnell O, Gräsbeck A, Ojesjö L, Otterbeck L
Department of Psychiatry, Lund University, Sweden.
Acta Psychiatr Scand. 1993 Nov;88(5):316-21. doi: 10.1111/j.1600-0447.1993.tb03466.x.
The Lundby study is a prospective, epidemiological survey of mental health in a total population. When evaluating the material of 2550 individuals followed from 1947 to 1972, we found a large group with mental tiredness as the dominating symptom. Next to depression this was the most frequent diagnosis in the population. According to our concept of Tiredness, one third of the women ran a lifetime risk of developing a first-ever episode of Tiredness, while the risk for men was one fifth. The incidence of Tiredness is described together with the total frequency of episodes. The course of mental illness starting with a first episode of Tiredness within the 25-year investigation period shows that about one third of the men and half of the women relapsed into Tiredness or other mental illnesses, not infrequently with a serious outcome. However, most of the episodes of Tiredness lasted less than 2 years and were of milder impairment. We emphasize the importance of further investigations by means of epidemiological, clinical and neurochemical methods as regards the heterogeneous syndrome of mental fatigue.
伦德比研究是一项针对全体人群心理健康的前瞻性流行病学调查。在评估1947年至1972年期间随访的2550名个体的资料时，我们发现有一大群人以精神疲劳为主要症状。仅次于抑郁症，这是该人群中最常见的诊断。根据我们对疲劳的概念，三分之一的女性一生中首次出现疲劳发作的风险，而男性的风险为五分之一。疲劳的发病率与发作的总频率一起描述。在25年的调查期内，以首次疲劳发作开始的精神疾病病程表明，约三分之一的男性和一半的女性复发为疲劳或其他精神疾病，其后果往往很严重。然而，大多数疲劳发作持续不到2年，且损害较轻。我们强调通过流行病学、临床和神经化学方法对精神疲劳的异质性综合征进行进一步研究的重要性。
