Buritova J, Honoré P, Chapman V, Besson J M
Physiopharmacologie du Système Nerveux, INSERM U.161, Paris, France.
Neurosci Lett. 1995 Mar 31;188(3):175-8. doi: 10.1016/0304-3940(95)11426-w.
Intraplantar carrageenan induced a peripheral inflammation and c-Fos like immunoreactivity (Fos-LI) in the dorsal horn, L4-L5 segments, of the rat spinal cord. The total number of control carrageenan evoked Fos-LI neurons was 126 +/- 6 per section, which were predominately located in the superficial and deep laminae (41 +/- 2% and 39 +/- 2% of the total number of Fos-LI neurons per section) of the dorsal horn. Pre-administered diclofenac (3, 6, 9 mg/kg i.v.) dose dependently reduced the number of Fos-LI neurons, with effects being strongest on the deep laminae Fos-LI neurons. The effects of diclofenac (9 mg/kg) on the number of Fos-LI neurons (68 +/- 2% reduction) and inflamed ankle (72 +/- 7% reduction) and paw (49 +/- 6% reduction) diameters, were positively correlated.
足底注射角叉菜胶可诱导大鼠脊髓L4-L5节段背角出现外周炎症和c-Fos样免疫反应性（Fos-LI）。对照组角叉菜胶诱发的Fos-LI神经元总数为每切片126±6个，主要位于背角的浅层和深层（分别占每切片Fos-LI神经元总数的41±2%和39±2%）。预先静脉注射双氯芬酸（3、6、9mg/kg）剂量依赖性地减少Fos-LI神经元数量，对深层Fos-LI神经元的作用最强。双氯芬酸（9mg/kg）对Fos-LI神经元数量（减少68±2%）、炎症踝关节直径（减少72±7%）和爪直径（减少49±6%）的影响呈正相关。
