Mendola J D, Cronin-Golomb A, Corkin S, Growdon J H
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, USA.
Optom Vis Sci. 1995 Mar;72(3):155-67. doi: 10.1097/00006324-199503000-00003.
This study addressed the issue of prevalence and pattern of visual deficits in 77 subjects with Alzheimer's disease (AD) and 111 healthy control subjects. We defined cutoff scores that would be expected from only 1 control subject of 100 (p = 0.01). The percentage of AD subjects who performed at or worse than this level varied across the 16 visual tests from a high of 58% to a low of 0%. The distribution of impairment across tests suggests a high vulnerability in AD of pattern vision, moderate vulnerability of spatial vision, and low vulnerability of motion and flicker perception. We found evidence for heterogeneity in the AD subject group: a subgroup (N = 14) emerged that was characterized by poor performance on the Backward Pattern Masking test, relatively young age, and relatively short duration of AD. Overall, the results indicate that visual dysfunction, especially on Backward Masking, is a common sign of AD.
本研究探讨了77名阿尔茨海默病（AD）患者和111名健康对照者的视力缺陷患病率及模式问题。我们定义了仅在100名对照者中有1人预期会出现的临界分数（p = 0.01）。在16项视觉测试中，表现等于或低于该水平的AD患者百分比从58%的高位到0%的低位不等。各项测试中损伤的分布表明，AD患者中模式视觉的易损性高，空间视觉的易损性中等，运动和闪烁感知的易损性低。我们发现AD患者组存在异质性的证据：出现了一个亚组（N = 14），其特征是在反向模式掩蔽测试中表现不佳、年龄相对较小且AD病程相对较短。总体而言，结果表明视觉功能障碍，尤其是反向掩蔽方面的功能障碍，是AD的常见体征。
