Platonov I A
Patol Fiziol Eksp Ter. 1995 Jan-Mar(1):16-9.
The mechanism of protective action of phenothiazine derivatives was studied by using a stochastic model of brain edema-swelling, which describes the relationship between various elements of vascular and cellular complexes in the nerve tissue. Each drug was found to have a preferable effect on particular morpho-functional structures: phenothiazine derivatives with a branched dialkylaminoalkyl chain exerted a protective action through the cellular complex and those with an unbranched chain affected through the vascular component of brain tissue. To increase a morphofunctional load on perivascular spaces is common to the agents in their mechanism of action.
通过使用脑水肿肿胀的随机模型研究了吩噻嗪衍生物的保护作用机制，该模型描述了神经组织中血管和细胞复合体各要素之间的关系。发现每种药物对特定的形态功能结构具有优先作用：具有支链二烷基氨基烷基链的吩噻嗪衍生物通过细胞复合体发挥保护作用，而具有直链的衍生物则通过脑组织的血管成分产生影响。增加血管周围间隙的形态功能负荷是这些药物作用机制的共同特点。
