[Protective action of phenothiazine derivatives in toxic edema-- swelling of the rat brain].

The mechanism of protective action of phenothiazine derivatives was studied by using a stochastic model of brain edema-swelling, which describes the relationship between various elements of vascular and cellular complexes in the nerve tissue. Each drug was found to have a preferable effect on particular morpho-functional structures: phenothiazine derivatives with a branched dialkylaminoalkyl chain exerted a protective action through the cellular complex and those with an unbranched chain affected through the vascular component of brain tissue. To increase a morphofunctional load on perivascular spaces is common to the agents in their mechanism of action.