阿替洛尔和普萘洛尔对脂肪分解的影响。
The effects of atenolol and propranolol upon lipolysis.
作者信息
Deacon S P
出版信息
Br J Clin Pharmacol. 1978 Feb;5(2):123-5. doi: 10.1111/j.1365-2125.1978.tb01611.x.
Abstract
1 The effects of selective and non-selective beta-adrenoceptor blockade upon plasma non-esterified fatty acid concentrations in the fasting state and following insulin stress have been studied in normal subjects. 2 Atenolol, propranolol and placebo were compared in a double-blind cross-over trial in eight normal subjects. 3 Atenolol and propranolol significantly lowered plasma non-esterified fatty acid concentrations by a similar degree in the fasting, non-stressed state. This finding suggests that beta1-adrenoceptors are involved in the control of basal lipolysis. 4 Following insulin-induced stress, lower plasma non-esterified fatty acid concentrations were observed with propranolol than with atenolol. This difference may be due to beta2-adrenoceptor involvement in the stress mechanisms controlling lipolysis, or to the differences in the water-lipid solubility properties of these drugs.
摘要
- 在正常受试者中，研究了选择性和非选择性β-肾上腺素能受体阻滞剂对空腹状态及胰岛素应激后血浆非酯化脂肪酸浓度的影响。2. 在一项双盲交叉试验中，对8名正常受试者比较了阿替洛尔、普萘洛尔和安慰剂。3. 在空腹、无应激状态下，阿替洛尔和普萘洛尔显著降低血浆非酯化脂肪酸浓度的程度相似。这一发现表明β1-肾上腺素能受体参与基础脂肪分解的控制。4. 胰岛素诱导应激后，观察到普萘洛尔组的血浆非酯化脂肪酸浓度低于阿替洛尔组。这种差异可能是由于β2-肾上腺素能受体参与控制脂肪分解的应激机制，或者是由于这些药物水脂溶性特性的差异。
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本文引用的文献
1
Effect of adrenergic blockade on glucose and fatty-acid mobilisation in man.肾上腺素能阻滞对人体葡萄糖和脂肪酸动员的影响。
Lancet. 1962 Aug 18;2(7251):316-7. doi: 10.1016/s0140-6736(62)90105-8.
2
Titration of free fatty acids of plasma: a study of current methods and a new modification.血浆游离脂肪酸的滴定：当前方法研究及一种新改良方法
J Lipid Res. 1960 Apr;1:199-202.
3
Plasma epinephrine and norepinephrine levels during insulin-induced hypoglycemia in man.人体胰岛素诱导低血糖期间的血浆肾上腺素和去甲肾上腺素水平。
J Clin Endocrinol Metab. 1961 Mar;21:296-304. doi: 10.1210/jcem-21-3-296.
4
Effect of beta-adrenergic blockade on resting and stimulated fat mobilization.β-肾上腺素能阻断对静息和刺激状态下脂肪动员的影响。
J Clin Endocrinol Metab. 1967 Oct;27(10):1441-50. doi: 10.1210/jcem-27-10-1441.
5
6
Sympathetic regulation of metabolism.新陈代谢的交感神经调节。
Pharmacol Rev. 1967 Sep;19(3):367-461.
7
Effects of small intravenous doses of epinephrine on serum insulin, glucose tolerance and serum free fatty acids.
Diabetes. 1974 Sep;23(9):743-7. doi: 10.2337/diab.23.9.743.
8
Effects of lipolytic and antilipolytic substances on adenosine 3',5'-monophosphate levels in isolated fat cells.脂解和抗脂解物质对分离脂肪细胞中3',5'-单磷酸腺苷水平的影响。
J Biol Chem. 1968 Apr 25;243(8):1705-12.
9
A new type of cardioselective adrenoceptive blocking drug.一种新型的心脏选择性肾上腺素能阻断药物。
Br J Pharmacol. 1973 Jun;48(2):340P.
10
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