Bressers W M, Kruk M R, Van Erp A M, Willekens-Bramer D C, Haccou P, Meelis E
Section Theoretical Biology, Institute of Evolutionary and Ecological Sciences, Leiden, The Netherlands.
Behav Neurosci. 1995 Dec;109(6):1158-71. doi: 10.1037//0735-7044.109.6.1158.
Stressors and different manipulations of the paraventricular nucleus of the hypothalamus (PVH) increase self-grooming in the rat. To assess the effect of these PVH manipulations on the timing of grooming in relation to other ongoing behavior, the authors describe these behavioral responses by a time-structured model. The authors show the following: (a) Behavior in each treatment group can be described by a semi-Markov model. Effects of treatments can be described as changes in the parameters of this model, which reflect the tendencies to start and stop grooming and other activities. (b) The PVH manipulations increase self-grooming by increasing the tendencies to start grooming or by extending the period during which grooming occurs. (c) Grooming responses are accompanied by an increase in activity. (d) Different PVH manipulations change the temporal structure of behavior differentially, suggesting that distinct mechanisms within the PVH are involved in the precise timing of grooming in relation to other activities.
应激源以及对下丘脑室旁核（PVH）的不同处理会增加大鼠的自我梳理行为。为了评估这些对PVH的处理对与其他正在进行的行为相关的梳理时间的影响，作者通过一个时间结构模型来描述这些行为反应。作者展示了以下内容：（a）每个治疗组的行为都可以用一个半马尔可夫模型来描述。治疗效果可以描述为该模型参数的变化，这些参数反映了开始和停止梳理及其他活动的倾向。（b）对PVH的处理通过增加开始梳理的倾向或延长梳理发生的时间段来增加自我梳理行为。（c）梳理反应伴随着活动的增加。（d）不同的PVH处理对行为的时间结构有不同的影响，这表明PVH内不同的机制参与了与其他活动相关的梳理的精确时间安排。
