Viglinskaya I V, Overstreet D H, Kashevskaya O P, Badishtov B A, Kampov-Polevoy A B, Seredenin S B, Halikas J A
Institute for Pharmacology, Russian Academy of Medical Sciences, Moscow.
Physiol Behav. 1995 May;57(5):937-41. doi: 10.1016/0031-9384(94)00368-f.
Previous reports have provided mixed results about emotional states in rats that voluntarily drink substantial amounts of alcohol. The purpose of the present study was to compare several strains of alcohol-preferring rats (P, AA, FH) with several strains of alcohol-nonpreferring rats (NP, ANA, FRL), and the Maudsley strains on tests reflecting anxiety and immobility. At about 70 days of age the rats were placed in the elevated plus maze for a 5-min test; a forced swim test of 10 min was given 4 days later and this test was followed 4 days later by a modified forced swim test (the capsule), in which there were four false escape alleys. The FRL rats spent more time in the open arms of the elevated plus maze than any other strain, but there was no consistent relationship between elevated plus maze scores and alcohol intake. The alcohol-preferring P rats were the most active in the standard forced swim test and the alcohol-nonpreferring Maudsley Reactive rats were the least active, but there was no consistent relationship between immobility and alcohol intake overall. All rats were much more active in the capsule and there were no significant strain differences. However, the alcohol-preferring P and FH rats attempted to escape more than the other strains, resulting in an overall significant correlation between escape attempts and alcohol intake. These findings do not provide any support for the hypothesis that alcohol-preferring rats are drinking alcohol to reduce high anxiety states.
先前的报告对于自愿大量饮酒的大鼠的情绪状态给出了不一致的结果。本研究的目的是比较几种嗜酒大鼠品系（P、AA、FH）与几种非嗜酒大鼠品系（NP、ANA、FRL），以及莫兹利品系在反映焦虑和不动状态的测试中的表现。在大约70日龄时，将大鼠置于高架十字迷宫中进行5分钟的测试；4天后进行10分钟的强迫游泳测试，再过4天后进行改良强迫游泳测试（胶囊测试），其中有四条假逃生通道。FRL大鼠在高架十字迷宫开放臂中停留的时间比其他任何品系都长，但高架十字迷宫得分与酒精摄入量之间没有一致的关系。嗜酒的P大鼠在标准强迫游泳测试中最活跃，而非嗜酒的莫兹利反应性大鼠最不活跃，但总体而言，不动时间与酒精摄入量之间没有一致的关系。所有大鼠在胶囊测试中都活跃得多，且品系间无显著差异。然而，嗜酒的P和FH大鼠比其他品系更倾向于尝试逃生，导致逃生尝试与酒精摄入量之间总体存在显著相关性。这些发现并不支持嗜酒大鼠饮酒是为了减轻高度焦虑状态这一假设。
