Badishtov B A, Overstreet D H, Kashevskaya O P, Viglinskaya I V, Kampov-Polevoy A B, Seredenin S B, Halikas J A
Institute for Pharmacology, Russian Academy of Medical Sciences, Moscow.
Physiol Behav. 1995 Mar;57(3):585-9. doi: 10.1016/0031-9384(94)00299-k.
High open field activity has been associated with high alcohol intake in inbred mouse strains. The present study sought to determine if a similar relationship might exist in rats. Strains which voluntarily drink large amounts of alcohol (alcohol-preferring [P], alcohol-accepting [AA], Fawn-Hooded [FH]) or little or no alcohol (alcohol-nonpreferring [NP], alcohol-nonaccepting [ANA], Flinders Resistant Line [FRL]) were compared with the Maudsley strains of rats selectively bred for differences in open field defecation and activity. There were highly significant strain differences in open field activity, with the alcohol-preferring P rats exhibiting the highest activity and the alcohol-nonpreferring Maudsley Reactive rats exhibiting the lowest. However, the NP rats were almost as active as the P rats and the AA and ANA rats exhibited intermediate levels of activity which did not differ from each other. Thus, there was no consistent relationship between open field activity and high voluntary alcohol intake. Defecation was highest in the Maudsley Reactive rats, and there was a consistent negative relationship with alcohol intake (r = -0.455 across all strains). In a population of 57 FHxFRL F2 hybrids, there were no significant correlations between alcohol intake and open field activity (r = -0.01) or defecation (r = +0.12). We conclude, therefore, that there was no consistent relationship between voluntary alcohol intake and open field behavior across strains of rats.
在近交系小鼠品系中，旷场活动量高与酒精摄入量高有关。本研究旨在确定大鼠中是否可能存在类似关系。将自愿大量饮酒的品系（嗜酒[P]、接受酒精[AA]、淡褐色带帽[FH]）或少量饮酒或不饮酒的品系（不嗜酒[NP]、不接受酒精[ANA]、弗林德斯抗性系[FRL]）与因旷场排便和活动差异而选择性培育的莫兹利大鼠品系进行比较。旷场活动存在高度显著的品系差异，嗜酒的P大鼠活动量最高，不嗜酒的莫兹利反应性大鼠活动量最低。然而，NP大鼠的活动量几乎与P大鼠相同，AA和ANA大鼠的活动量处于中间水平，彼此无差异。因此，旷场活动与高自愿酒精摄入量之间没有一致的关系。莫兹利反应性大鼠的排便量最高，且与酒精摄入量呈一致的负相关（所有品系的r = -0.455）。在57只FHxFRL F2杂交种群体中，酒精摄入量与旷场活动（r = -0.01）或排便（r = +0.12）之间无显著相关性。因此，我们得出结论，大鼠品系间自愿酒精摄入量与旷场行为之间没有一致的关系。
