Moran A, Jones A, Asquith P
Dept. of Medicine, University of Bristol, England.
Scand J Gastroenterol. 1995 Apr;30(4):356-60. doi: 10.3109/00365529509093290.
Previous studies have not identified a convenient laboratory marker of colonoscopic activity in Crohn's colitis or ulcerative colitis.
Twenty-eight patients with either ulcerative colitis or Crohn's colitis undergoing colonoscopy by the same observed had laboratory measurements of serum albumin, orosomucoid, C-reactive protein, plasma viscosity, haemoglobin, leucocyte and platelet counts, and faecal alpha-1-antitrypsin from single non-lyophilized samples. Multiple linear regression was performed using each laboratory variable as the dependent variable and the lengths of each grade of endoscopic activity as the explanatory variables.
Multiple regression analysis using all the endoscopic grades of acute activity showed significant correlations with faecal alpha-1-antitrypsin (p < 0.001), serum albumin (p < 0.001), C-reactive protein (p = 0.02), and plasma viscosity (p = 0.03).
The highest multiple correlation coefficients were obtained with faecal alpha-1-antitrypsin (r = 0.82) and serum albumin (r = 0.80), and these measurements can be recommended as convenient markers of endoscopic activity in these diseases.
既往研究尚未确定克罗恩病性结肠炎或溃疡性结肠炎结肠镜检查活动的便捷实验室标志物。
28例溃疡性结肠炎或克罗恩病性结肠炎患者接受同一名观察者的结肠镜检查，对单次非冻干样本进行血清白蛋白、类粘蛋白、C反应蛋白、血浆粘度、血红蛋白、白细胞和血小板计数以及粪便α1抗胰蛋白酶的实验室检测。以每个实验室变量作为因变量，各内镜活动分级的长度作为解释变量进行多元线性回归分析。
使用急性活动的所有内镜分级进行的多元回归分析显示，与粪便α1抗胰蛋白酶（p<0.001）、血清白蛋白（p<0.001）、C反应蛋白（p=0.02）和血浆粘度（p=0.03）有显著相关性。
粪便α1抗胰蛋白酶（r=0.82）和血清白蛋白（r=0.80）的多元相关系数最高，这些检测可作为这些疾病内镜活动的便捷标志物推荐使用。
