Versteeg D H, Van Der Gugten J, De Jong W, Palkovits M
Brain Res. 1976 Sep 3;113(3):563-74. doi: 10.1016/0006-8993(76)90057-3.
The concentrations of noradrenaline and lopamine of 92 brain regions have been measured by a radiometric method which enabled discrimination between noradrenaline and adrenaline. Almost all brain regions investigated contained both noradrenaline and lopamine in measurable amount. However, both catecholamines appeared to be unevenly distributed. Very high dopamine concentrations were measured in the olfactory tubercle, the nucleus accumbens, the caudate nucleus and the rostral part of the medial forebrain bundle; the globus pallidus, the nucleus tractus diagonalis and the nucleus septalis lateralis were also very rich in dopamine. Outside the telencephalon the dopamine concentrations were rather low, except in the median eminence and the area tegmentalis ventralis (Tsai), an area corresponding to the A10 region. High noradrenaline concentrations were measured in most hypothalamic nuclei. Relatively high concentrations of this catecholamine were also measured in several mesencephalic (the ventral part of the central gray, the nucleus raphe dorsalis and the nucleus cuneiformis) and pontine (the locus coeruleus and the nuclei parabrachiales) regions. The highest noradrenaline concentrations in the medulla oblongata were observed in the A2 region and the nucleus commissuralis, which contained at least twice as much noradrenaline as did the more rostral part of the nucleus tractus solitarii.
采用一种能区分去甲肾上腺素和肾上腺素的放射测量法，测定了92个脑区中去甲肾上腺素和洛巴明的浓度。几乎所有被研究的脑区都含有可测量量的去甲肾上腺素和洛巴明。然而，这两种儿茶酚胺的分布似乎并不均匀。在嗅结节、伏隔核、尾状核和内侧前脑束的前端部分检测到非常高的多巴胺浓度；苍白球、斜角带核和外侧隔核中多巴胺含量也非常丰富。在端脑之外，多巴胺浓度相当低，除了正中隆起和腹侧被盖区（蔡氏区），该区域对应于A10区。在大多数下丘脑核中检测到高浓度的去甲肾上腺素。在几个中脑（中央灰质腹侧部分、中缝背核和楔形核）和脑桥（蓝斑和臂旁核）区域也检测到相对较高浓度的这种儿茶酚胺。在延髓中，去甲肾上腺素浓度最高的区域是A2区和连合核，其去甲肾上腺素含量至少是孤束核较前端部分的两倍。
