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[莱姆病与心肌病]

[Lyme borreliosis and cardiomyopathy].

作者信息

Bergler-Klein J, Ullrich R, Glogar D, Stanek G

机构信息

Abteilung für Kardiologie, Klinik für Innere Medizin, Wien.

出版信息

Wien Med Wochenschr. 1995;145(7-8):196-8.

PMID:7610674
Abstract

According to current opinion there is acute, self-limiting Lyme carditis, and chronic Lyme carditis. Acute Lyme carditis manifests mostly as transient conduction disorders of the heart (e.g. AV-blocking I to III), and as supraventricular and ventricular rhythm disturbances, pericarditis, myocarditis, and pancarditis in single cases. Chronic Lyme carditis is defined as a case of chronic heart failure confirmed by positive serology and endomyocardial biopsy. Anamnestic aid is rare. Neither tick-bites nor preceding or accompanying erythema chronicum migrans are constantly reported. Seropositivity and control of its specificity by western blot are indicative but no etiological proof. Even histological detection of spirochetes in endomyocardial tissue or cultivation of borrelia from endomyocardial biopsy are no final etiological proof of the respective cardial disorder. Those findings, however, are an indication for antibiotic treatment. According to the severity of the disorder, antibiotics are administered orally (penicillin or derivatives) or parenterally with penicillin or cephalosporins of the 3rd generation over 4 and 2 weeks, respectively.

摘要

根据目前的观点,存在急性自限性莱姆病性心脏炎和慢性莱姆病性心脏炎。急性莱姆病性心脏炎主要表现为心脏的短暂传导障碍(如Ⅰ至Ⅲ度房室传导阻滞),以及室上性和室性心律失常、心包炎、心肌炎,个别情况下还可出现全心炎。慢性莱姆病性心脏炎定义为经血清学阳性和心内膜活检证实的慢性心力衰竭病例。既往病史帮助不大。蜱叮咬以及先前或伴随的慢性游走性红斑并非总是有报告。血清阳性以及通过免疫印迹法对其特异性的检测具有指示意义,但并非病因学证据。即使在心内膜组织中通过组织学检测到螺旋体或从心内膜活检中培养出疏螺旋体,也不能作为相应心脏疾病的确切病因学证据。然而,这些发现是抗生素治疗的指征。根据病情严重程度,抗生素分别口服(青霉素或其衍生物)或静脉注射第三代青霉素或头孢菌素,疗程分别为4周和2周。

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