Sallmén M, Lindbohm M L, Kyyrönen P, Nykyri E, Anttila A, Taskinen H, Hemminki K
Department of Epidemiology and Biostatistics, Institute of Occupational Health, Helsinki, Finland.
Am J Ind Med. 1995 May;27(5):699-713. doi: 10.1002/ajim.4700270506.
A retrospective time-to-pregnancy study was performed among women biologically monitored for exposure to organic solvents. The women were participants in a previous study on spontaneous abortion. They were classified into exposure categories on the basis of work description and the use of solvents as reported in the questionnaires and on biological exposure measurements. Daily or high solvent exposure, adjusted for potential confounders, was significantly associated with reduced fecundability in the discrete proportional hazards analysis (incidence density ratio of clinical pregnancies 0.41; 95% confidence interval [CI] 0.27-0.62). The incidence density ratios were decreased also among workers who were exposed to organic solvents in shoe factories (0.28; CI 0.11-0.71), dry cleaning shops (0.44; CI 0.22-0.86), and in the metal industry (0.58; CI 0.34-0.98). The possible effects of various biases are discussed. The results of the study support the hypothesis that daily or high exposure to organic solvents is associated with reduced fertility. There is a need for safer working methods in industries where organic solvents still are used.
对接受有机溶剂暴露生物监测的女性进行了一项回顾性受孕时间研究。这些女性是先前一项关于自然流产研究的参与者。根据问卷中报告的工作描述和溶剂使用情况以及生物暴露测量结果，将她们分为不同的暴露类别。在离散比例风险分析中，经潜在混杂因素调整后，每日或高剂量溶剂暴露与生育力降低显著相关（临床妊娠的发病率密度比为0.41；95%置信区间[CI]为0.27 - 0.62）。在鞋厂（0.28；CI为0.11 - 0.71）、干洗店（0.44；CI为0.22 - 0.86）和金属行业（0.58；CI为0.34 - 0.98）中接触有机溶剂的工人中，发病率密度比也有所降低。讨论了各种偏倚的可能影响。该研究结果支持以下假设：每日或高剂量接触有机溶剂与生育力降低有关。在仍使用有机溶剂的行业中，需要更安全的工作方法。
