Sallmén M, Anttila A, Lindbohm M L, Kyyrönen P, Taskinen H, Hemminki K
Finnish Institute of Occupational Health, Helsinki, Finland.
J Occup Environ Med. 1995 Aug;37(8):931-4. doi: 10.1097/00043764-199508000-00007.
A retrospective time-to-pregnancy study was conducted among women biologically monitored for exposure to lead. The women were participants of a previous study on spontaneous abortion. They were classified into exposure categories on the basis of questionnaire information, and individual blood lead (B-Pb) measurements. The adjusted incidence density ratios (IDR) of clinically recognized pregnancies were .93 (95% confidence interval [CI] .56 to 1.57) for very low (B-Pb < .5 mumol/L), .84 (CI .48 to 1.45) for low (B-Pb .5 to .9 mumol/L), and .80 (CI 0.42 to 1.54) for higher (B-Pb > or = 1.0 mumol/L) exposure compared with no exposure, in the discrete proportional hazards analysis. Exposure to inorganic lead was not associated with fecundability at current, low-exposure levels. The suggestive finding among the eight most heavily exposed women (B-Pb 1.4 to 2.4 mumol/L, IDR .53; CI .19 to 1.52) should be confirmed or refuted in a larger study.
对接受生物监测以评估铅暴露情况的女性进行了一项回顾性受孕时间研究。这些女性是先前一项关于自然流产研究的参与者。根据问卷调查信息和个体血铅（B-Pb）测量结果，她们被分为不同的暴露类别。在离散比例风险分析中，与无暴露组相比，临床确认妊娠的调整发病率密度比（IDR）在极低暴露组（B-Pb < 0.5 μmol/L）为0.93（95%置信区间[CI] 0.56至1.57），低暴露组（B-Pb 0.5至0.9 μmol/L）为0.84（CI 0.48至1.45），高暴露组（B-Pb≥1.0 μmol/L）为0.80（CI 0.42至1.54）。在当前低暴露水平下，无机铅暴露与生育力无关。在暴露最严重的八名女性（B-Pb 1.4至2.4 μmol/L，IDR 0.53；CI 0.19至1.52）中得到的提示性发现，应在更大规模的研究中得到证实或反驳。
