Kristensen J, Langhoff-Roos J, Kristensen F B
Department of Obstetrics and Gynecology, University Hospital (Rigshospitalet), Copenhagen, Denmark.
Obstet Gynecol. 1993 Jun;81(6):1005-8.
To determine the relation between cervical conization and preterm birth.
All Danish women with singleton pregnancies who gave birth to their first infant in 1982 and second infant during the time period 1982-1987 were included in a register-based cohort study. Information on pregnancy outcome and cervical conization in 1977-1987 was obtained from the Medical Birth Register and the National Register of Hospital Discharges.
In a cohort of 14,233 women, 170 had cervical conization. Thirty-four had cervical conization before the first delivery, 62 between the first and the second, and 74 after the second delivery. Women with cervical conization had a significantly higher risk of preterm birth. In addition, women with subsequent cervical conization had a higher risk of preterm birth in previous pregnancies. However, the risk of preterm birth was higher in women with previous than with subsequent cervical conization.
Cervical conization is correlated with preterm birth. Because women with subsequent cervical conization have an increased risk of preterm birth in preceding pregnancies, factors other than the surgical intervention may contribute to the significantly increased risk of preterm birth.
确定宫颈锥切术与早产之间的关系。
所有在1982年生育第一胎且在1982 - 1987年期间生育第二胎的丹麦单胎妊娠妇女被纳入一项基于登记的队列研究。1977 - 1987年期间的妊娠结局和宫颈锥切术信息来自医疗出生登记册和国家医院出院登记册。
在一个由14233名妇女组成的队列中，170人进行了宫颈锥切术。34人在首次分娩前进行了宫颈锥切术，62人在首次和第二次分娩之间进行了宫颈锥切术，74人在第二次分娩后进行了宫颈锥切术。进行宫颈锥切术的妇女早产风险显著更高。此外，随后进行宫颈锥切术的妇女在前次妊娠中早产风险更高。然而，前次进行宫颈锥切术的妇女比随后进行宫颈锥切术的妇女早产风险更高。
宫颈锥切术与早产相关。由于随后进行宫颈锥切术的妇女在前次妊娠中早产风险增加，手术干预以外的因素可能导致早产风险显著增加。
