Møller B R, Johannesen P, Osther K, Ulmsteen U, Hastrup J, Berg K
Obstet Gynecol. 1983 Nov;62(5):625-9.
Human leukocyte interferon was incorporated into a hydrophilic gel and applied to the cervix of six patients suffering from moderate to severe dysplasia or carcinoma in situ of the cervix. Only patients showing no spontaneous regression during at least 27 consecutive weeks were admitted to the trial. The diagnoses were established by Papanicolaou smears and biopsy specimens of the cervix. The gel was applied directly on the cervix twice weekly for six weeks, and only minor clinical improvements were seen. However, after an additional six weeks, six of six patients responded positively; three of them regressed completely. No side effects were noted.
将人白细胞干扰素加入亲水性凝胶中，并应用于6例患有中度至重度发育异常或宫颈原位癌的患者的宫颈。只有那些在至少连续27周内未出现自发消退的患者才被纳入该试验。诊断通过巴氏涂片和宫颈活检标本确定。凝胶每周直接应用于宫颈两次，持续六周，仅观察到轻微的临床改善。然而，在额外的六周后，6例患者中有6例反应呈阳性；其中3例完全消退。未观察到副作用。
