Easmon J, Heinisch G, Holzer W, Matuszczak B
Institute of Pharmaceutical Chemistry, University of Innsbruck, Austria.
Arch Pharm (Weinheim). 1995 Apr;328(4):307-12. doi: 10.1002/ardp.19953280403.
Preparation of series of pyridine-, pyridazine-, and pyrazine-derived carboxamides bearing at the ring N-atom an alkyl side-chain with a terminal carboxylic group (7-11) or with a terminal acetylamino malonic ester moiety (13-17, 19-23) is described. Two desaza-pyridazomycin derivatives (24, 26) and homologs thereof (25, 27) were synthesised. The novel compounds which are structurally related to the antifungal antibiotic pyridazomycin were screened for antifungal activity: preliminary in vitro tests showed no activity.
