Riabchikov O P, Shmeleva S P, Chuich N A, Khlystova Z S, Kalinina I I, Rabotnikova E L, Sibakova I S, Gerasiuta G I, Lobusov E V
Arkh Patol. 1995 Mar-Apr;57(2):61-4.
Percentage and mitotic regimen (mitotic index, mitotic phases, pathological mitosis) of hematopoietic liver cells of the embryos and foetuses (6-12 weeks of development) from females living in normal conditions (Moscow) and in polluted with radionuclides after Chernobyl accident territory of Bryansk region of Russian Federation (towns Novozybkov and Klintsy) are characterized. Moderate but statistically significant (P < 0.05) differences were found in the number of polychromatophilic and oxyphilic normoblasts, basophilic megaloblasts, granulocytes at various developmental stages in the study group compared to the control. No difference was observed in 1992 in the mitotic activity, total number of pathological mitoses and the percentage of binuclear cells. But the spectrum of pathological mitoses, in the contaminated zone, seems to be wider. The mitotic index and the number of cells per 1 mg of organ tissue showed two-fold increase in 1993 in the town of Novozybkov as compared to the control area. The conclusion is made that small radiation doses exert only very slight influence on hematopoiesis in human embryonic and foetal liver of 6-12 weeks of gestation.
对生活在正常环境（莫斯科）的女性以及生活在俄罗斯联邦布良斯克地区切尔诺贝利事故后受放射性核素污染地区（新兹布科夫镇和克林齐镇）的女性所产胚胎和胎儿（发育6 - 12周）的肝脏造血细胞的百分比和有丝分裂情况（有丝分裂指数、有丝分裂期、病理性有丝分裂）进行了表征。与对照组相比，研究组中嗜多色性和嗜酸性正成红细胞、嗜碱性巨成红细胞以及不同发育阶段粒细胞的数量存在适度但具有统计学意义（P < 0.05）的差异。1992年，有丝分裂活性、病理性有丝分裂总数以及双核细胞百分比未观察到差异。但在受污染区域，病理性有丝分裂的谱似乎更宽。与对照区域相比，1993年新兹布科夫镇每1毫克器官组织的有丝分裂指数和细胞数量增加了两倍。得出的结论是，小剂量辐射对妊娠6 - 12周的人类胚胎和胎儿肝脏造血仅产生非常轻微的影响。
