Bar-Meir E, Teuber S S, Lin H C, Alosacie I, Goddard G, Terybery J, Barka N, Shen B, Peter J B, Blank M
Research Unit of Autoimmune Disease, Sheba Medical Center, Tel-Hashomer, Israel.
J Autoimmun. 1995 Apr;8(2):267-77. doi: 10.1006/jaut.1995.0020.
Diverse immunologic abnormalities have been described in women who received silicone breast implants. However, most studies have focused on either a limited number of patients or a small panel of autoantibodies. We report the analysis of 20 autoantibodies in 116 women with implants and 134 controls. The patients ranged from 26- to 66-years-old, with a mean of 45.7 +/- 8.3 years; breast prostheses were in place for a mean of 15 +/- 5.6 years, with a range of 4 to 30, the chief complaints of the 116 patients included polyarthralgias, fatigue, myalgias, morning stiffness, and decreased memory. All 250 sera were tested blindly using a panel of 20 autoantigens including SS-A, SS-B, RNP, cardiolipin (CL), collagen types I, II and IV, phosphatidylserine (PS), myeloperoxidase (MPO), sulfatides (sulf), thyroglobulin (TG), gangliosides (GDIa;GM2), proteinase-3 (PR3), Jo-1, Sm, HPRPP-ribosomal phosphate, histones (H2AH2B), Scl-70 and glomerular basement membrane (NC-1). Values from individual patients were considered positive only when greater than 3 SD above the control mean. There was a statistically significant greater frequency of autoantibodies in women with implants for 15 of the 20 autoantigens; these were particularly striking for anti-H2AH2B, HPRPP, SS-A, SS-B, Scl-70, CL, PS, GM2, and NC-1. Many patients harbored several autoantibodies; 20% had four autoantibodies; 8% had six autoantibodies. The association of autoantibodies and implants suggests an adjuvant action of silicon/silicone byproducts.
接受硅胶乳房植入物的女性中已发现多种免疫异常情况。然而，大多数研究要么聚焦于有限数量的患者，要么只检测一小部分自身抗体。我们报告了对116名植入假体的女性和134名对照者的20种自身抗体的分析结果。患者年龄在26岁至66岁之间，平均年龄为45.7±8.3岁；乳房假体植入时间平均为15±5.6年，范围为4至30年，116名患者的主要症状包括多关节痛、疲劳、肌痛、晨僵和记忆力减退。使用包含20种自身抗原的检测组对所有250份血清进行盲测，这些自身抗原包括SS - A、SS - B、RNP、心磷脂（CL）、I型、II型和IV型胶原蛋白、磷脂酰丝氨酸（PS）、髓过氧化物酶（MPO）、硫脂（sulf）、甲状腺球蛋白（TG）、神经节苷脂（GDIa；GM2）、蛋白酶 - 3（PR3）、Jo - 1、Sm、HPRPP - 核糖体磷酸、组蛋白（H2AH2B）、Scl - 70和肾小球基底膜（NC - 1）。仅当个体患者的值高于对照平均值3个标准差以上时才被视为阳性。在20种自身抗原中的15种上，植入假体的女性中自身抗体的出现频率在统计学上显著更高；抗H2AH2B、HPRPP、SS - A、SS - B、Scl - 70、CL、PS、GM2和NC - 1的情况尤为明显。许多患者体内存在多种自身抗体；20%的患者有四种自身抗体；8%的患者有六种自身抗体。自身抗体与植入物之间的关联表明硅/硅胶副产物具有佐剂作用。
