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葡萄球菌γ-溶血素的LukF先进行关键结合，随后HγII结合以实现人红细胞的溶血。

Essential binding of LukF of staphylococcal gamma-hemolysin followed by the binding of H gamma II for the hemolysis of human erythrocytes.

作者信息

Ozawa T, Kaneko J, Kamio Y

机构信息

Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.

出版信息

Biosci Biotechnol Biochem. 1995 Jun;59(6):1181-3. doi: 10.1271/bbb.59.1181.

DOI:10.1271/bbb.59.1181
PMID:7613012
Abstract

Staphylococcal gamma-hemolysin consists of two protein components, LukF and H gamma II. This report clarifies the order of binding of the two components to human erythrocytes for the hemolytic activity of the toxin. The initial binding of LukF to the human erythrocytes is essential for the subsequent binding of H gamma II to the same cells, with the formation of a heat-undissociable protein of about 100 kDa containing LukF and H gamma II.

摘要

葡萄球菌γ-溶血素由两种蛋白质成分LukF和HγII组成。本报告阐明了这两种成分与人红细胞结合的顺序，以实现毒素的溶血活性。LukF与人红细胞的初始结合对于随后HγII与同一细胞的结合至关重要，会形成一种约100 kDa的热稳定蛋白，其中包含LukF和HγII。

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