Sudo K, Choorit W, Asami I, Kaneko J, Muramoto K, Kamio Y
Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.
Biosci Biotechnol Biochem. 1995 Sep;59(9):1786-9. doi: 10.1271/bbb.59.1786.
The staphylococcal toxin gamma-hemolysin consists of two protein components, LukF and H gamma II. Staphylococcus aureus P83 was found to have five components, LukF, LukF-PV, LukM, LukS, and H gamma II for leukocidin or gamma-hemolysin. H gamma II of S. aureus P83 was demonstrated to be a naturally-occurring analogous molecule of H gamma II [H gamma II(P83)], in which the 217th arginine residue was replaced by lysine. The H gamma II(P83) showed about 50% of the hemolytic activity of normal H gamma II in the presence of LukF.
葡萄球菌毒素γ-溶血素由两种蛋白质成分LukF和HγII组成。发现金黄色葡萄球菌P83具有五种成分，即用于杀白细胞素或γ-溶血素的LukF、LukF-PV、LukM、LukS和HγII。金黄色葡萄球菌P83的HγII被证明是HγII [HγII(P83)]的天然类似分子，其中第217位精氨酸残基被赖氨酸取代。在存在LukF的情况下，HγII(P83)显示出正常HγII约50%的溶血活性。
