Gray B A, Hyde R W, Hodges M, Yu P N
Circulation. 1979 Mar;59(3):551-9. doi: 10.1161/01.cir.59.3.551.
To characterize the changes in lung volumes after acute myocardial infarction (AMI), and the relationship of these changes to other alterations in lung function which correlate with the severity of pulmonary vascular congestion, we made measurements of pulmonary hemodynamics, lung volume, closing volume, frequency dependence of total pulmonary resistance to forced oscillation, and arterial PO2 in 18 subjects with AMI. The most consistent finding was reduced lung volume which correlated with the severity of pulmonary diastolic hypertension. Frequency dependence of resistance showed a small but significant correlation with pulmonary hemodynamics. Closing volume measurements by the resident gas method in nine subjects was not related to hemodynamics. Follow-up studies at the time of hospital discharge revealed a significant return toward normal for arterial PO2, all lung volumes, and total pulmonary resistance at 9 Hz. Based on measurements in healthy subjects, the reduced lung volume after AMI may explain the changes in resistance. In acute and follow-up studies the degree of lung volume reduction and the severity of hypoxemia were strongly correlated.
为了描述急性心肌梗死（AMI）后肺容积的变化，以及这些变化与其他肺功能改变的关系（这些改变与肺血管充血的严重程度相关），我们对18例AMI患者进行了肺血流动力学、肺容积、闭合容积、总肺阻力对强迫振荡的频率依赖性以及动脉血氧分压的测量。最一致的发现是肺容积减少，这与肺舒张压升高的严重程度相关。阻力的频率依赖性与肺血流动力学有小但显著的相关性。用残气法对9例患者进行的闭合容积测量与血流动力学无关。出院时的随访研究显示，动脉血氧分压、所有肺容积以及9赫兹时的总肺阻力显著恢复正常。基于对健康受试者的测量，AMI后肺容积减少可能解释了阻力的变化。在急性和随访研究中，肺容积减少的程度与低氧血症的严重程度密切相关。
