Lamey P J, McCartan B E, MacDonald D G, MacKie R M
School of Clinical Dentistry, Queen's University of Belfast, U.K.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jan;79(1):44-9. doi: 10.1016/s1079-2104(05)80072-1.
One hundred sixty-one patients with a clinical diagnosis of an oral lichenoid reaction were evaluated serologically for circulating autoantibodies toward basal cell membrane components. The study group comprised 119 women and 42 men with a median age of 59 and 55 years, respectively. Most patients (n = 144) had an oral mucosal biopsy undertaken. Serologic investigation aimed to identify an IgG antibody that, under immunofluorescent staining, produced an annular fluorescence of basal cells and that has been referred to as basal cell cytoplasmic antibody. These basal cell cytoplasmic antibodies were significantly associated with systemic drug usage, histologic diagnosis of a lichenoid reaction, and a unilateral intraoral distribution of the clinical lesion. In the diagnosis of oral lichenoid reactions precipitated by drug therapy, the basal cell cytoplasmic phenomenon may be a useful adjunct to clinical and histologic investigation.
对161例临床诊断为口腔苔藓样反应的患者进行了血清学检测，以检测针对基底细胞膜成分的循环自身抗体。研究组包括119名女性和42名男性，中位年龄分别为59岁和55岁。大多数患者（n = 144）进行了口腔黏膜活检。血清学检测旨在鉴定一种IgG抗体，该抗体在免疫荧光染色下可使基底细胞产生环状荧光，被称为基底细胞胞质抗体。这些基底细胞胞质抗体与全身用药、苔藓样反应的组织学诊断以及临床病变的单侧口腔内分布显著相关。在诊断药物治疗引起的口腔苔藓样反应时，基底细胞胞质现象可能是临床和组织学检查的有用辅助手段。
