Angastiniotis M, Modell B, Englezos P, Boulyjenkov V
Thalassaemia Centre, Ministry of Health, Nicosia, Cyprus.
Bull World Health Organ. 1995;73(3):375-86.
In many developing countries the haemoglobinopathies (thalassaemias and sickle-cell disorder) are so common that they provide a convenient model for working out a genetic approach to control of chronic childhood diseases. At present, about 250 million people (4.5% of the world population) carry a potentially pathological haemoglobinopathy gene. Each year about 300,000 infants are born with major haemoglobinopathies. Haemoglobinopathy control programmes, based on WHO approaches and recommendations, have been established in different countries in all WHO Regions and have been successful in management of the problem. Following WHO recommendations the health burden of hereditary anaemias could be significantly reduced. This article summarizes the presentations and discussion made at a joint WHO/TIF (Thalassaemia International Federation) meeting, held in Cyprus in April 1993, and reviews the experience of programmes in several countries for the control of haemoglobinopathies in the world.
在许多发展中国家，血红蛋白病（地中海贫血和镰状细胞病）非常普遍，为制定控制儿童慢性疾病的遗传方法提供了一个便利的模型。目前，约有2.5亿人（占世界人口的4.5%）携带潜在病理性血红蛋白病基因。每年约有30万婴儿出生时患有严重的血红蛋白病。基于世界卫生组织的方法和建议，不同国家在世卫组织所有区域都建立了血红蛋白病控制项目，并在解决这一问题方面取得了成功。按照世界卫生组织的建议，遗传性贫血的健康负担可大幅减轻。本文总结了1993年4月在塞浦路斯举行的世界卫生组织/地中海贫血国际联合会联合会议上的发言和讨论内容，并回顾了世界上几个国家控制血红蛋白病项目的经验。
