围产期接触二噁英类化合物研讨会。III. 内分泌影响。
Workshop on perinatal exposure to dioxin-like compounds. III. Endocrine effects.
作者信息
Feeley M M
机构信息
Bureau of Chemical Safety, Health and Welfare Canada, Tunney's Pasture, Ottawa, Ontario.
出版信息
Environ Health Perspect. 1995 Mar;103 Suppl 2(Suppl 2):147-50. doi: 10.1289/ehp.95103s2147.
Abstract
Studies involving endocrine effects in humans and experimental animals resulting from the exposure to dioxin-like (non-ortho-substituted PCBs, PCDDs/PCDFs) and nondioxin-like (PCBs, OC pesticides) compounds (DLCs and NDLCs) were presented. A variety of reproductive and hormonal parameters, including androgen status, sexual differentiation, and thyroid functionality, were discussed. As in utero and lactational exposure of the human fetus/neonate to these environmental contaminants is inevitable, continued research to identify sensitive biomarkers of effect and susceptibility, as well as to define dose-response relationships, is required.
摘要
介绍了有关人类和实验动物接触二噁英类（非邻位取代多氯联苯、多氯二苯并二噁英/多氯二苯并呋喃）和非二噁英类（多氯联苯、有机氯农药）化合物（二噁英类化合物和非二噁英类化合物）所产生内分泌影响的研究。讨论了包括雄激素状态、性分化和甲状腺功能在内的各种生殖和激素参数。由于人类胎儿/新生儿在子宫内和哺乳期不可避免地会接触这些环境污染物，因此需要持续开展研究，以确定效应和易感性的敏感生物标志物，并确定剂量反应关系。
相似文献
1
Workshop on perinatal exposure to dioxin-like compounds. III. Endocrine effects.围产期接触二噁英类化合物研讨会。III. 内分泌影响。
Environ Health Perspect. 1995 Mar;103 Suppl 2(Suppl 2):147-50. doi: 10.1289/ehp.95103s2147.
2
NTP technical report on the toxicology and carcinogenesis studies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in female Harlan Sprague-Dawley rats (Gavage Studies).美国国家毒理学计划（NTP）关于2,3,7,8-四氯二苯并对二恶英（TCDD）（化学物质登记号：1746-01-6）对雌性哈兰·斯普拉格-道利大鼠毒理学及致癌性研究的技术报告（灌胃研究）
Natl Toxicol Program Tech Rep Ser. 2006 Apr(521):4-232.
3
Workshop on perinatal exposure to dioxin-like compounds. I. Summary.围产期接触二噁英类化合物研讨会。I. 总结。
Environ Health Perspect. 1995 Mar;103 Suppl 2(Suppl 2):135-42. doi: 10.1289/ehp.103-1518837.
4
Workshop on perinatal exposure to dioxin-like compounds. II. Reproductive effects.围产期接触二噁英类化合物研讨会。II. 生殖影响。
Environ Health Perspect. 1995 Mar;103 Suppl 2(Suppl 2):143-5. doi: 10.1289/ehp.95103s2143.
5
Relationship between the concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in maternal blood and those in breast milk.母体血液与母乳中多氯二苯并对二恶英、多氯二苯并呋喃和多氯联苯浓度的关系。
Chemosphere. 2010 Jan;78(2):185-92. doi: 10.1016/j.chemosphere.2009.09.047. Epub 2009 Oct 21.
6
Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood and breast milk collected from 60 mothers in Sapporo City, Japan.从日本札幌市60名母亲采集的血液和母乳中多氯代二苯并 - 对 - 二恶英、多氯代二苯并呋喃及类二恶英多氯联苯的浓度。
Chemosphere. 2008 Jul;72(8):1152-8. doi: 10.1016/j.chemosphere.2008.03.050. Epub 2008 May 12.
7
Workshop on perinatal exposure to dioxin-like compounds. VI. Role of biomarkers.围产期接触二噁英类化合物研讨会。VI.生物标志物的作用。
Environ Health Perspect. 1995 Mar;103 Suppl 2(Suppl 2):161-7. doi: 10.1289/ehp.95103s2161.
8
NTP technical report on the toxicology and carcinogenesis studies of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (Gavage studies).国家毒理学计划关于2,2',4,4',5,5'-六氯联苯（多氯联苯153）（化学物质登记号：35065-27-1）对雌性哈兰·斯普拉格-道利大鼠毒理学及致癌性研究的技术报告（灌胃研究）
Natl Toxicol Program Tech Rep Ser. 2006 May(529):4-168.
9
Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan.从日本札幌市195名孕妇采集的血液中多氯代二苯并 - 对 - 二噁英、多氯代二苯并呋喃及二噁英类多氯联苯的浓度。
Chemosphere. 2007 Oct;69(8):1228-37. doi: 10.1016/j.chemosphere.2007.05.083. Epub 2007 Jul 12.
引用本文的文献
1
A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio.一项关于子宫内多氯联苯（PCB）暴露与出生性别比关系的队列研究。
Environ Health. 2008 Jul 15;7:37. doi: 10.1186/1476-069X-7-37.
本文引用的文献
1
Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat.围产期暴露于特定多氯联苯同系物对大鼠甲状腺激素浓度和甲状腺组织学的影响。
Toxicol Lett. 1993 Jun;68(3):311-23. doi: 10.1016/0378-4274(93)90023-q.
2
Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats.多氯联苯对胎鼠和新生大鼠肝脏及脑甲状腺激素代谢的干扰。
Toxicol Appl Pharmacol. 1993 Sep;122(1):27-33. doi: 10.1006/taap.1993.1168.
3
Regulation of gene expression by thyroid hormone.甲状腺激素对基因表达的调控。
J Clin Invest. 1988 Apr;81(4):957-67. doi: 10.1172/JCI113449.
4
Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects on growth, morbidity, and duration of lactation.母乳中的多氯联苯（PCBs）和二氯二苯二氯乙烯（DDE）：对生长、发病率及哺乳期时长的影响
Am J Public Health. 1987 Oct;77(10):1294-7. doi: 10.2105/ajph.77.10.1294.
5
Environmental occurrence, abundance, and potential toxicity of polychlorinated biphenyl congeners: considerations for a congener-specific analysis.多氯联苯同系物的环境存在、丰度及潜在毒性：同系物特异性分析的考量因素
Environ Health Perspect. 1989 May;81:225-39. doi: 10.1289/ehp.8981225.
6
Maturation of the secretion of thyroid hormone and thyroid-stimulating hormone in the fetus.胎儿甲状腺激素及促甲状腺激素分泌的成熟过程。
N Engl J Med. 1991 Feb 21;324(8):532-6. doi: 10.1056/NEJM199102213240805.
7
In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 1. Effects on androgenic status.雄性大鼠在子宫内和哺乳期暴露于2,3,7,8-四氯二苯并对二恶英。1. 对雄激素状态的影响。
Toxicol Appl Pharmacol. 1992 May;114(1):97-107. doi: 10.1016/0041-008x(92)90101-w.
8
In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 3. Effects on spermatogenesis and reproductive capability.雄性大鼠在子宫内和哺乳期暴露于2,3,7,8-四氯二苯并对二恶英。3. 对精子发生和生殖能力的影响。
Toxicol Appl Pharmacol. 1992 May;114(1):118-26. doi: 10.1016/0041-008x(92)90103-y.
9
In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 2. Effects on sexual behavior and the regulation of luteinizing hormone secretion in adulthood.雄性大鼠在子宫内和哺乳期暴露于2,3,7,8-四氯二苯并对二恶英。2. 对成年期性行为和促黄体生成素分泌调节的影响。
Toxicol Appl Pharmacol. 1992 May;114(1):108-17. doi: 10.1016/0041-008x(92)90102-x.
Zotero 插件