Meissner P, Dorow P, Thalhofer S, Heinemann S
Abteilung Pneumologie, DRK Krankenhaus Mark Brandenburg, Akademisches Lehrkrankenhaus, FU Berlin.
Pneumologie. 1995 Mar;49 Suppl 1:187-9.
In 1,150 patients with sleep apnea syndrome, the apnea number, the morning theophyllin level, the symptom of morning exhaustion were recorded for the first night of theophyllin therapy and in the follow-up period of up to 5 years; in addition, side effects were noted at the end of the observation period. Prior to start of the therapy, the average apnea number was 97 per night; this decreased to 25 per night in the initial therapy. In the observation period of between 3 and 28 months, the number of apnea phases increased slightly on average. The symptoms of morning exhaustion initially decreased to 60% but increased again by about 20% over the next five years. In responders, theophyllin reduces the number of apnea in the long term course; however, frequent therapy controls are needed to determine the optimal dosage. Longitudinally, patients with an apnea index < 20/profited most from this drug therapy.
在1150例睡眠呼吸暂停综合征患者中，记录了茶碱治疗第一晚及长达5年随访期内的呼吸暂停次数、晨起茶碱水平、晨起疲惫症状；此外，在观察期结束时记录了副作用。治疗开始前，平均每晚呼吸暂停次数为97次；初始治疗时降至每晚25次。在3至28个月的观察期内，呼吸暂停阶段的数量平均略有增加。晨起疲惫症状最初降至60%，但在接下来的五年中又增加了约20%。在有反应者中，茶碱可在长期病程中减少呼吸暂停次数；然而，需要频繁的治疗监测以确定最佳剂量。纵向来看，呼吸暂停指数<20/的患者从这种药物治疗中获益最大。
