Schäfer H H, Grieger E, Heitmann J, Koehler U, Peter J H, Ploch T, Weber K
Medizinische Poliklinik, Philipps-Universität Marburg.
Pneumologie. 1993 Dec;47 Suppl 4:741-6.
Among all the sleep-related respiratory disorders, sleep apnoea is clinically the most important one because of its high incidence and potential cardiovascular sequelae. Treatment depends upon the risk profile of the individual patient; in severe cases or in risk patients nasal continuous superpressure ventilation is employed, whereas in milder cases theophylline has been successfully used alongside general measures. 103 patients were followed up during treatment on an outpatient basis for 2 to maximum 12 months. Initially a significant reduction of the apnoea index by a 50% average was achieved. This therapeutical effect remained largely constant with a slight average deterioration at the end of the observation period, whereas the subjective feeling tone also improved in most patients. The treatment course was prematurely discontinued in 34 patients. Good to very good success was achieved in a total of 43 patients, whereas 26 patients were non-responders either initially or as the treatment proceeded. Even though theophylline treatment is now well-tried in mild forms of sleep apnoea, predictors for its use in certain groups of patients must be determined before treatment is initiated.
在所有与睡眠相关的呼吸障碍中，睡眠呼吸暂停在临床上最为重要，因其发病率高且具有潜在的心血管后遗症。治疗方法取决于个体患者的风险状况；在严重病例或高危患者中采用鼻腔持续正压通气，而在较轻病例中，氨茶碱已与一般措施一起成功使用。103例患者在门诊治疗期间接受了2至最长12个月的随访。最初，呼吸暂停指数平均显著降低了50%。这种治疗效果在很大程度上保持稳定，在观察期结束时平均略有恶化，而大多数患者的主观感觉也有所改善。34例患者提前终止了治疗过程。共有43例患者取得了良好至非常好的疗效，而26例患者在初始阶段或治疗过程中无反应。尽管氨茶碱治疗目前在轻度睡眠呼吸暂停形式中已得到充分验证，但在开始治疗前必须确定其在某些患者群体中使用的预测指标。
