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晚间服用缓释茶碱对睡眠呼吸暂停的长期治疗

[Long-term treatment of sleep apnea with evening administration of oral retard theophylline].

作者信息

Dorow P, Thalhofer S, Heinemann S, Meissner P, Kühler U

机构信息

Abt. Pneumologie, DRK-Krankenhaus Mark Brandenburg, Akademisches Lehrkrankenhaus, Freien Universität Berlin.

出版信息

Pneumologie. 1993 Dec;47 Suppl 4:778-9.

PMID:8153109
Abstract

In 776 patients suffering from sleep apnoea long-term treatment with sustained-release theophylline was investigated. Responders show a significant reduction of apnoea phases. Using an individual theophylline dosage with morning theophylline concentrations between 5 and 8 micrograms/ml, only few side effects occurred. Positive effects on cardiopulmonary capacity were seen.

摘要

对776例患有睡眠呼吸暂停的患者进行了长效缓释茶碱长期治疗的研究。有反应者的呼吸暂停阶段显著减少。采用个体化茶碱剂量，使早晨的茶碱浓度在5至8微克/毫升之间，仅出现了少数副作用。观察到对心肺功能有积极影响。

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1
[Long-term treatment of sleep apnea with evening administration of oral retard theophylline].晚间服用缓释茶碱对睡眠呼吸暂停的长期治疗
Pneumologie. 1993 Dec;47 Suppl 4:778-9.
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