Hein H, Kirsten D, Jugert C, Magnussen H
Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, LVA Freie und Hansestadt Hamburg.
Pneumologie. 1993 Dec;47 Suppl 4:750-3.
We examined the effect of 375 mg theophylline at night in 95 patients (14 women, 81 men) with obstructive sleep apnoea. The apnoea-hypopnoea index decreased significantly from 20.9 +/- 17.2 to 13.5 +/- 15.8/hour, the nadir of oxygen saturation increased from 80.6 +/- 8.5 to 82.4 +/- 8%. A survey of the longterm effects of theophylline in 16 initially responding patients revealed after 31-922 (190 +/- 217) days therapy no statistically significant change of the apnoea-hypopnoea index; however, the nadir of oxygen saturation was lower compared to the beginning of the therapy (83.8 +/- > 79.3 +/- 7.6%). We believe that theophylline is useful in single cases of patients with obstructive sleep apnoea, but is necessary to reconfirm the positive effect.
我们研究了夜间给予95例阻塞性睡眠呼吸暂停患者（14名女性，81名男性）375毫克茶碱的效果。呼吸暂停低通气指数从20.9±17.2显著降至13.5±15.8次/小时，氧饱和度最低点从80.6±8.5升至82.4±8%。对16例最初有反应的患者进行的茶碱长期效果调查显示，在31 - 922（190±217）天的治疗后，呼吸暂停低通气指数无统计学显著变化；然而，氧饱和度最低点与治疗开始时相比更低（83.8±>79.3±7.6%）。我们认为茶碱对个别阻塞性睡眠呼吸暂停患者有用，但有必要再次确认其积极效果。
